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Schultz, T.W.; Dawson, D.A.; Lin, D.T. Comparative toxicity of selected nitrogen-containing aromatic compounds in the Tetrahymena pyriformis and Pimephales promelas test systems. Chemosphere 1989, 18, 11, 2283–2291.

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Schultz, T.W.; Dawson, D.A.; Lin, D.T. Comparative toxicity of selected nitrogen-containing aromatic compounds in the Tetrahymena pyriformis and Pimephales promelas test systems. Chemosphere 1989, 18, 11, 2283–2291.

QDB archive DOI: 10.15152/QDB.39   DOWNLOAD

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Property pIGC50: 48-h Tetrahymena toxicity as log(1/IGC50) [log(L/mmol)]

2: All compounds

Regression model (regression)

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Name Type n

R2

σ

Training training 37 0.625 0.463

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When using this QDB archive, please cite (see details) it together with the original article:

  • Ruusmann, V. Data for: Comparative toxicity of selected nitrogen-containing aromatic compounds in the Tetrahymena pyriformis and Pimephales promelas test systems. QsarDB repository, QDB.39. 2012. http://dx.doi.org/10.15152/QDB.39

  • Schultz, T. W.; Dawson, D. A.; Lin, D. T. Comparative toxicity of selected nitrogen-containing aromatic compounds in the Tetrahymena pyriformis and Pimephales promelas test systems. Chemosphere 1989, 18, 2283–2291.

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dc.date.accessioned 2012-05-23T15:47:55Z
dc.date.available 2012-05-23T15:47:55Z
dc.date.issued 2012-05-23
dc.identifier.uri http://hdl.handle.net/10967/39
dc.identifier.uri http://dx.doi.org/10.15152/QDB.39
dc.description.abstract The relative toxicity of a heterogeneous series of nitrogen-containing aromatics including substituted anilines, pyridines and nitrobenzenes was evaluated in the 48-h sublethal, static Tetrahymena pyriformis (ciliate protozoan) test system and compared with reported values for the 96-h lethal, flow-through Pimephales promelas (fathead minnow) test system. The log octanol/water partition coefficient-dependent (log Kow) linear regression analysis of each data set revealed no linear relationship owing to the fact that several modes of toxic action were represented by the tested aromatics. Regression analysis of the fathead minnow toxicity (log LC50 [M/l]) versus Tetrahymena toxicity (log BR [mM/l] showed good correlation between the two systems as revealed by the model log LC50 = -1.091 (log BR) - 3.284; n = 38, r-square = 0.887, s = 0.319, f = 282.75, Pr > f = 0.0001.
dc.publisher Villu Ruusmann
dc.rights Attribution 4.0 International
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Schultz, T.W.; Dawson, D.A.; Lin, D.T. Comparative toxicity of selected nitrogen-containing aromatic compounds in the Tetrahymena pyriformis and Pimephales promelas test systems. Chemosphere 1989, 18, 11, 2283–2291.
qdb.property.endpoint 6. Other (Acute toxicity to ciliate protozoa)
qdb.property.species Tetrahymena pyriformis
qdb.descriptor.application ClogP
bibtex.entry article
bibtex.entry.author Schultz, T. W.
bibtex.entry.author Dawson, D. A.
bibtex.entry.author Lin, D. T.
bibtex.entry.journal Chemosphere
bibtex.entry.number 11
bibtex.entry.pages 2283–2291
bibtex.entry.title Comparative toxicity of selected nitrogen-containing aromatic compounds in the Tetrahymena pyriformis and Pimephales promelas test systems
bibtex.entry.volume 18
bibtex.entry.year 1989
qdb.model.type Regression model (regression)


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