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Schultz, T.W.; Applehans, F.M.; Riggin, G.W. Structure-activity relationships of selected pyridines: III. Log Kow analysis. Ecotoxicol. Environ. Saf. 1987, 13, 1, 76–83.

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Schultz, T.W.; Applehans, F.M.; Riggin, G.W. Structure-activity relationships of selected pyridines: III. Log Kow analysis. Ecotoxicol. Environ. Saf. 1987, 13, 1, 76–83.

QDB archive DOI: 10.15152/QDB.25   DOWNLOAD

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Property pIGC50: 60-h Tetrahymena toxicity as log(1/IGC50) [log(L/mmol)]

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dc.date.accessioned 2012-05-23T15:40:07Z
dc.date.available 2012-05-23T15:40:07Z
dc.date.issued 2012-05-23
dc.identifier.uri http://hdl.handle.net/10967/25
dc.identifier.uri http://dx.doi.org/10.15152/QDB.25
dc.description.abstract Twenty 2- and 3-position derivatives of pyridine (C5H5N) were tested following a short-term static protocol. Biological activity was monitored as population growth of Tetrahymena pyriformis. These data were combined with previously reported data for twenty 4-position derivatives. Structure-activity relationships were examined using Kow as the physicochemical descriptor. These data form three linear models: one for the non-H-polar derivatives and two for the H-polar derivatives. The latter two models are parallel but have no obvious basis for a priori selectivity. HPLC analysis for toxicant persistence shows that only the smaller non-H-polar derivatives have any significant abiotic loss over the duration of the biological testing.
dc.publisher Villu Ruusmann
dc.rights Attribution 4.0 International
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Schultz, T.W.; Applehans, F.M.; Riggin, G.W. Structure-activity relationships of selected pyridines: III. Log Kow analysis. Ecotoxicol. Environ. Saf. 1987, 13, 1, 76–83.
qdb.property.endpoint 6. Other (Acute toxicity to ciliate protozoa)
qdb.property.species Tetrahymena pyriformis
bibtex.entry article
bibtex.entry.author Schultz, T. W.
bibtex.entry.author Applehans, F. M.
bibtex.entry.author Riggin, G. W.
bibtex.entry.doi 10.1016/0147-6513(87)90044-3
bibtex.entry.journal Ecotoxicol. Environ. Saf.
bibtex.entry.number 1
bibtex.entry.pages 76–83
bibtex.entry.title Structure-activity relationships of selected pyridines: III. Log Kow analysis
bibtex.entry.volume 13
bibtex.entry.year 1987


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