When using this QDB archive, please cite (see details) it together with the original article:
Ruusmann, V. Data for: Structure-activity relationships of selected pyridines: III. Log Kow analysis. QsarDB repository, QDB.25. 2012. http://dx.doi.org/10.15152/QDB.25
Schultz, T. W.; Applehans, F. M.; Riggin, G. W. Structure-activity relationships of selected pyridines: III. Log Kow analysis. Ecotoxicol. Environ. Saf. 1987, 13, 76–83. http://dx.doi.org/10.1016/0147-6513(87)90044-3
Title: | Schultz, T.W.; Applehans, F.M.; Riggin, G.W. Structure-activity relationships of selected pyridines: III. Log Kow analysis. Ecotoxicol. Environ. Saf. 1987, 13, 1, 76–83. |
Abstract: | Twenty 2- and 3-position derivatives of pyridine (C5H5N) were tested following a short-term static protocol. Biological activity was monitored as population growth of Tetrahymena pyriformis. These data were combined with previously reported data for twenty 4-position derivatives. Structure-activity relationships were examined using Kow as the physicochemical descriptor. These data form three linear models: one for the non-H-polar derivatives and two for the H-polar derivatives. The latter two models are parallel but have no obvious basis for a priori selectivity. HPLC analysis for toxicant persistence shows that only the smaller non-H-polar derivatives have any significant abiotic loss over the duration of the biological testing. |
URI: | http://hdl.handle.net/10967/25
http://dx.doi.org/10.15152/QDB.25 |
Date: | 2012-05-23 |
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