Abstract: All compounds are considered to act by polar narcosis. This is well established for non-reactive compounds. Acute lethality is brought about by accumulation in cellular membranes causing their disruption and ultimately death of the organism. The ability of the compound to accumulate in a cellular membrane is thought to be related to its intrinsic hydrophobicity. ...

Abstract: QSARINS (QSAR-INSUBRIA) is a new software for the development and validation of multiple linear regression Quantitative Structure-Activity Relationship (QSAR) models by Ordinary Least Squares method and Genetic Algorithm for variable selection. This program is mainly focused on the external validation of QSAR models. Various tools for explorative analysis of ...

Abstract: The purpose of the analyses presented in this report was to contribute to an evaluation of the possibility of using QSAR predictions for regulatory purposes. To this end QSAR predictions were compared with SIDS test data. Furthermore, the models were also assessed according to the extent to which they meet OECD principles for QSAR validation (OECD ENV/JM/Mon ...