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Abstract

The purpose of the analyses presented in this report was to contribute to an evaluation of the possibility of using QSAR predictions for regulatory purposes. To this end QSAR predictions were compared with SIDS test data. Furthermore, the models were also assessed according to the extent to which they meet OECD principles for QSAR validation (OECD ENV/JM/Mono(2004)24). It is emphasized that the comparisons are not intended to be scientific validations, because the SIDS test chemicals were not selected to ensure that they are sufficiently diverse and representative for the entire applicability domain of the individual models. Nevertheless, many of the analyses presented here form the basis for scientific validation.