Schultz, T.W.; Sinks, G.D.; Miller, L.A. Population Growth Impairment of Sulfur-Containing Compounds to Tetrahymena pyriformis. Environ. Toxicol. 2001, 16, 6, 543–549.

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Schultz, T.W.; Sinks, G.D.; Miller, L.A. Population Growth Impairment of Sulfur-Containing Compounds to Tetrahymena pyriformis. Environ. Toxicol. 2001, 16, 6, 543–549.

QDB archive DOI: 10.15152/QDB.87   DOWNLOAD

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Property pIGC50: 40-h Tetrahymena toxicity as log(1/IGC50) [log(L/mmol)]

1: Nonpolar narcosis

Regression model (regression)

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  • Ruusmann, V. Data for: Population Growth Impairment of Sulfur-Containing Compounds to Tetrahymena pyriformis. QsarDB repository, QDB.87. 2012. http://dx.doi.org/10.15152/QDB.87

  • Schultz, T. W.; Sinks, G. D.; Miller, L. A. Population Growth Impairment of Sulfur-Containing Compounds to Tetrahymena pyriformis. Environ. Toxicol. 2001, 16, 543–549. http://dx.doi.org/10.1002/tox.10015

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dc.date.accessioned2012-05-23T16:14:53Z
dc.date.available2012-05-23T16:14:53Z
dc.date.issued2012-05-23
dc.identifier.urihttp://hdl.handle.net/10967/87
dc.identifier.urihttp://dx.doi.org/10.15152/QDB.87
dc.description.abstractA series of 37 aliphatic and aromatic sulfur-containing compounds were evaluated in 2-day Tetrahymena pyriformis population growth impairment assay. The results indicate that, except for select compounds, the in-ring sulfur-containing compounds, sulfates, sulfites, thiols, sulfones, and sulfoxides model as neutral and noncovalent-reacting narcotics. Abiotic loss due to volatility appears to interfere in accurate model prediction because actual toxicity was less than predicted. Vinyl sulfones and sulfoxides are more toxic than predicted using neutral narcosis. Tetrahymena exposed to methyl vinyl sulfone exhibits a direct relationship between the exposure concentration and the generation times with no lag phase in growth. As such, these population growth kinetics mimic those reported for hydrophilic neutral narcotics (i.e., ethanol and acetone). Tetrahymena exposed to phenyl vinyl sulfone exhibit a long concentration-dependent lag phase, which is followed by population growth at rates not different from controls. These population growth kinetics are similar but more dramatic than those reported for hydrophobic neutral narcotics (i.e., butylbenzene and 2-decanone). These results are useful in that they imply that sulfur-containing compounds for the most part act as simple narcotics. Therefore, their toxicity can be modeled with simple structure-toxicity relationships without much fear of underestimation of potency.
dc.publisherVillu Ruusmann
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleSchultz, T.W.; Sinks, G.D.; Miller, L.A. Population Growth Impairment of Sulfur-Containing Compounds to Tetrahymena pyriformis. Environ. Toxicol. 2001, 16, 6, 543–549.
qdb.property.endpoint6. Other (Acute toxicity to ciliate protozoa)
qdb.property.speciesTetrahymena pyriformis
qdb.descriptor.applicationClogP
qdb.descriptor.applicationMOPAC
bibtex.entryarticle
bibtex.entry.authorSchultz, T. W.
bibtex.entry.authorSinks, G. D.
bibtex.entry.authorMiller, L. A.
bibtex.entry.doi10.1002/tox.10015
bibtex.entry.journalEnviron. Toxicol.
bibtex.entry.number6
bibtex.entry.pages543–549
bibtex.entry.titlePopulation Growth Impairment of Sulfur-Containing Compounds to Tetrahymena pyriformis
bibtex.entry.volume16
bibtex.entry.year2001
qdb.model.typeRegression model (regression)


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