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Schultz, T.W.; Seward-Nagel, J.; Foster, K.A.; Tucker, V.A. Population Growth Impairment of Aliphatic Alcohols to Tetrahymena. Environ. Toxicol. 2004, 19, 1, 1–10.

QsarDB Repository

Schultz, T.W.; Seward-Nagel, J.; Foster, K.A.; Tucker, V.A. Population Growth Impairment of Aliphatic Alcohols to Tetrahymena. Environ. Toxicol. 2004, 19, 1, 1–10.

QDB archive DOI: 10.15152/QDB.82   DOWNLOAD

QsarDB content

Property pIGC50: 2-day Tetrahymena toxicity as log(1/IGC50) [log(L/mmol)]

1: Narcotic alcohols

Regression model (regression)

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Name Type n

R2

σ

Training training 67 0.954 0.238
2: 2-Alkenols

Regression model (regression)

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Name Type n

R2

σ

Training training 18 0.929 0.335
3: Primary homopropargylic alcohols

Regression model (regression)

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Name Type n

R2

σ

Training training 8 0.985 0.165
4: Secondary homopropargylic alcohols

Regression model (regression)

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Name Type n

R2

σ

Training training 5 0.962 0.133
5: Non-reactive alcohols

Regression model (regression)

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Name Type n

R2

σ

Training training 98 0.935 0.294
6: Primary propargylic alcohols

Regression model (regression)

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Name Type n

R2

σ

Training training 10 0.969 0.211
7: All alcohols

Regression model (regression)

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Name Type n

R2

σ

Training training 120 0.870 0.407

Citing

When using this QDB archive, please cite (see details) it together with the original article:

  • Ruusmann, V. Data for: Population Growth Impairment of Aliphatic Alcohols to Tetrahymena. QsarDB repository, QDB.82. 2012. http://dx.doi.org/10.15152/QDB.82

  • Schultz, T. W.; Seward-Nagel, J.; Foster, K. A.; Tucker, V. A. Population Growth Impairment of Aliphatic Alcohols to Tetrahymena. Environ. Toxicol. 2004, 19, 1–10. http://dx.doi.org/10.1002/tox.10145

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dc.date.accessioned 2012-05-23T16:12:04Z
dc.date.available 2012-05-23T16:12:04Z
dc.date.issued 2012-05-23
dc.identifier.uri http://hdl.handle.net/10967/82
dc.identifier.uri http://dx.doi.org/10.15152/QDB.82
dc.description.abstract The toxicity of a series of 120 aliphatic alcohols was evaluated using the Tetrahymena pyriformis population growth impairment assay. For tertiary propargylic alcohols; primary, secondary, and tertiary homopropargylic alcohols; allylic alcohols; and saturated alcohols, a statistically robust structure-activity model was developed for toxicity data [log (IGC(50)(-1))] using the 1-octanol/water partition coefficient (log K(ow)) as the lone descriptor [log (IGC(50))(-1) = 0.74 (log K(ow)) - 1.73; n = 97; r(2) (adj.) = 0.933; r(2) (pred.) = 0.932; s = 0.298; F = 1328; Pr > F = 0.0001]. Analysis of data for the primary propargylic alcohols yielded a separate, high-quality log K(ow)-dependent quantitative structure-activity relationship (QSAR) [log (IGC(50))(-1) = 0.65 (log K(ow)) - 1.22; n = 10; r(2) (adj.) = 0.969; r(2) (pred.) = 0.964; s = 0.222; F = 254; Pr > F = 0.0001]. A comparison of the observed toxicity and that predicted by the first QSAR showed that the primary propargylic alcohols with log K(ow) values < 2.00 exhibited enhanced toxicity and that this increased toxicity was inversely related to hydrophobicity. In sharp contrast, analysis of the data for the secondary propargylic alcohols exhibited little relationship with log K(ow) (r(2) = 0.339). Although the initial QSAR can be used to model the toxicity of any aliphatic alcohol for the T. pyriformis population growth impairment end point, the estimated potency would be underestimated for primary propargylic alcohols with log K(ow) values < 2.00. Moreover, estimates of toxic potency of secondary propargylic alcohols based on this QSAR should be viewed with limited confidence. The findings for beta-unsaturated alcohols in Tetrahymena were sharply different from that reported for fathead minnow acute mortality; this difference in toxicity is a result of a difference in the protocol used rather than in metabolism.
dc.publisher Villu Ruusmann
dc.rights Attribution 4.0 International
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Schultz, T.W.; Seward-Nagel, J.; Foster, K.A.; Tucker, V.A. Population Growth Impairment of Aliphatic Alcohols to Tetrahymena. Environ. Toxicol. 2004, 19, 1, 1–10.
qdb.property.endpoint 6. Other (Acute toxicity to ciliate protozoa)
qdb.property.species Tetrahymena pyriformis
qdb.descriptor.application ClogP
bibtex.entry article
bibtex.entry.author Schultz, T. W.
bibtex.entry.author Seward-Nagel, J.
bibtex.entry.author Foster, K. A.
bibtex.entry.author Tucker, V. A.
bibtex.entry.doi 10.1002/tox.10145
bibtex.entry.journal Environ. Toxicol.
bibtex.entry.number 1
bibtex.entry.pages 1–10
bibtex.entry.title Population Growth Impairment of Aliphatic Alcohols to Tetrahymena
bibtex.entry.volume 19
bibtex.entry.year 2004
qdb.model.type Regression model (regression)


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