Cajina-Quezada, M.; Schultz, T.W. Structure-toxicity relationships for selected weak acid respiratory uncouplers. Aquat. Toxicol. 1990, 17, 3, 239–252.

Abstract

The relative biological response (log BR) for each of 30 select substituted phenols and anilines was evaluated using the 48-h Tetrahymena pyriformis population growth test system. Simple linear regression analysis of log BR versus log Kow (1-octanol/water partition coefficient) was used to formulate a quantitative structure-activity relationship (QSAR). The equation, log BR = 0.438 (log Kow) + 0.157; n = 27, r2 = 0.933, s = 0.151, f = 348.02, is a highly predictive model. An evaluation of data on fathead minnow mortality for these same compounds shows a similar QSAR, log LC50 = -0.590 (log Kow) - 3.247; n = 11, r2 = 0.917, s = 0.287, f = 99.04. These relationships are the respective QSARs for the respiratory uncoupling mechanism of action of selected weak acids. Moreover, the toxic response in the two systems are highly correlated (r2 = 0.915).