Regression model (regression)
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Name | Type | n |
R2 |
σ |
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Training | training | 27 | 0.646 | 0.542 |
When using this QDB archive, please cite (see details) it together with the original article:
Ruusmann, V. Data for: Relationships of quantitative structure-activity to comparative toxicity of selected phenols in the Pimephales promelas and Tetrahymena pyriformis test systems. QsarDB repository, QDB.24. 2012. http://dx.doi.org/10.15152/QDB.24
Schultz, T. W.; Holcombe, G. W.; Phipps, G. L. Relationships of quantitative structure-activity to comparative toxicity of selected phenols in the Pimephales promelas and Tetrahymena pyriformis test systems. Ecotoxicol. Environ. Saf. 1986, 12, 146–153. http://dx.doi.org/10.1016/0147-6513(86)90051-5
Title: | Schultz, T.W.; Holcombe, G.W.; Phipps, G.L. Relationships of quantitative structure-activity to comparative toxicity of selected phenols in the Pimephales promelas and Tetrahymena pyriformis test systems. Ecotoxicol. Environ. Saf. 1986, 12, 2, 146–153. |
Abstract: | The relative toxic response of 27 selected phenols in the 96-hr acute flowthrough Pimephales promelas (fathead minnow) and the 48- to 60-hr chronic static Tetrahymena pyriformis (ciliate protozoan) test systems was evaluated. Log Kow-dependent linear regression analyses revealed that the data from each test system consisted of two linear equations. The less toxic chemicals form a relationship which models polar narcosis; these chemicals are slightly more active than the baseline toxicity of nonionic narcotic chemicals. The more toxic chemicals form a relationship which models uncoupling of oxidative phosphorylation. Regression analysis of fathead minnow toxicity (log LC50 (mol/liter] vs Tetrahymena toxicity (log BR (mmol/liter] showed good correlation between the two systems. An exception appears to be 4-nitrophenol, which is more active in the Tetrahymena system than in the fathead minnow and lies outside the 95% confidence interval. Reanalysis following deletion of 4-nitrophenol results in the equation log LC50 = -0.9192 (log BR) -3.5035; n = 26, r2 = 0.887. |
URI: | http://hdl.handle.net/10967/24
http://dx.doi.org/10.15152/QDB.24 |
Date: | 2012-05-23 |
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0147651386900515.qdb.zip | n/a | application/zip | 4.774Kb | View/ |