University of Tartu, Institute of Chemistry, Molecular Technology (Estonia)
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Browsing University of Tartu, Institute of Chemistry, Molecular Technology (Estonia) by Title "Experimental Reactivity Parameters for Toxicity Modeling: Application to the Acute Aquatic Toxicity of SN2 Electrophiles to Tetrahymena pyriformis"

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Browsing University of Tartu, Institute of Chemistry, Molecular Technology (Estonia) by Title "Experimental Reactivity Parameters for Toxicity Modeling: Application to the Acute Aquatic Toxicity of SN2 Electrophiles to Tetrahymena pyriformis"

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Roberts, D.W.; Schultz, T.W.; Wolf, E.M.; Aptula, A.O. Experimental Reactivity Parameters for Toxicity Modeling: Application to the Acute Aquatic Toxicity of SN2 Electrophiles to Tetrahymena pyriformis. Chem. Res. Toxicol. 2010, 23, 1, 228–234.

Published: Villu Ruusmann (2012-05-23)

Abstract: A diverse set of 60 haloaliphatic compounds were evaluated for reactivity with cysteine thiol groups in the previously described RC(50) assay using glutathione (GSH) as a model nucleophile. Reactivity was quantified by the RC(50) value, the concentration of test compound that produced 50% reaction of the GSH thiol groups in 120 min. Under standard conditions, ...

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