Cronin, M.T.D.; Schultz, T.W. Structure-toxicity relationships for phenols to Tetrahymena pyriformis. Chemosphere 1996, 32, 8, 1453–1468.

166 compounds | Property pIGC50: 2-day Tetrahymena toxicity as log(1/IGC50) [log(L/mmol)]

ID	Name	pIGC50	Details
1	3-hydroxybenzaldehyde	0.085	View
2	nonylphenol	2.468	View
3	2,4-dimethylphenol	0.070	View
4	4-bromophenol	0.680	View
5	4-cresol	-0.184	View
6	4-chlorophenol	0.545	View
7	3-cresol	-0.063	View
8	3-chlorophenol	0.871	View
9	3,5-dimethylphenol	0.113	View
10	phenol	-0.208	View
11	2-chloro-4,5-dimethylphenol	0.688	View
12	3,5-di-tert-butylphenol	1.638	View
13	2,4,6-tribromophenol	2.030	View
14	2-hydroxyacetophenone	0.078	View
15	ethyl-4-hydroxybenzoate	0.573	View
16	2,4-dichlorophenol	1.036	View
17	3-ethoxy-4-hydroxybenzaldehyde	0.015	View
18	3-methoxy-4-hydroxybenzaldehyde	-0.030	View
19	3-hydroxyacetophenone	-0.381	View
20	4-butoxyphenol	0.701	View
21	4-ethylphenol	0.205	View
22	4-hydroxybenzaldehyde	0.266	View
23	2,6-di-tert-butyl-4-methylphenol	1.796	View
24	4-heptyloxyphenol	2.033	View
25	syringaldehyde	0.168	View
26	4-tert-octylphenol	2.097	View
27	4-chloro-3-ethylphenol	1.081	View
28	4-methylcyanophenol	-0.384	View
29	3-methoxysalicylaldehyde	0.377	View
30	3-methoxyphenol	-0.326	View
31	4-methoxyphenol	-0.143	View
32	4-cyclopentylphenol	1.292	View
33	4-chloro-2-methylphenol	0.701	View
34	2-allylphenol	0.334	View
35	6-tert-butyl-2,4-dimethylphenol	1.157	View
36	4-hexyloxyphenol	1.638	View
37	methyl-3-hydroxybenzoate	-0.046	View
38	5-bromo-2-hydroxybenzylalcohol	0.343	View
39	4-bromo-2,6-dimethylphenol	1.167	View
40	2-tert-butyl-4-methylphenol	1.301	View
41	2,3,6-trimethylphenol	0.277	View
42	3-chloro-4-fluorophenol	1.131	View
43	2,6-difluorophenol	0.471	View
44	5-bromovanillin	0.617	View
45	2-hydroxy-4,5-dimethylacetophenone	0.707	View
46	2-fluorophenol	0.185	View
47	2,4-difluorophenol	0.604	View
48	4-fluorophenol	0.017	View
49	3-fluorophenol	0.381	View
50	2,6-dichloro-4-fluorophenol	0.804	View
51	α,α,α-trifluoro-4-cresol	0.618	View
52	2,3,4,5-tetrachlorophenol	2.712	View
53	3,5-dimethoxyphenol	-0.092	View
54	4-hydroxyphenethylalcohol	-0.826	View
55	2,3-dimethylphenol	0.122	View
56	3,4,5-trimethylphenol	0.932	View
57	2,4,6-trimethylphenol	0.281	View
58	4-iodophenol	0.854	View
59	2,3-dichlorophenol	1.276	View
60	3,4,5,6-tetrabromo-2-methylphenol	2.574	View
61	2,5-dichlorophenol	1.125	View
62	3-tert-butylphenol	0.730	View
63	4-chloro-3-methylphenol	0.796	View
64	3-bromophenol	1.145	View
65	3,5-dichlorophenol	1.569	View
66	pentabromophenol	2.664	View
67	2-cyanophenol	0.034	View
68	2,4-dibromophenol	1.398	View
69	2-chloro-5-methylphenol	0.393	View
70	3-isopropylphenol	0.612	View
71	4-hydroxybenzamide	-0.780	View
72	3-ethylphenol	0.228	View
73	3-hydroxybenzylalcohol	-1.043	View
74	3-hydroxy-4-methoxybenzaldehyde	-0.141	View
75	4-ethoxyphenol	0.013	View
76	3-iodophenol	1.119	View
77	4-propylphenol	0.643	View
78	2-hydroxybenzamide	-0.242	View
79	3-chloro-5-methoxyphenol	0.757	View
80	3-ethoxy-4-methoxyphenol	-0.299	View
81	2-bromo-4-methylphenol	0.599	View
82	2,3,5-trimethylphenol	0.360	View
83	4-bromo-2,6-dichlorophenol	1.778	View
84	4-hydroxypropiophenone	0.053	View
85	4-bromo-3,5-dimethylphenol	1.268	View
86	4-bromo-6-chloro-2-methylphenol	1.276	View
87	4-cyanophenol	0.516	View
88	2,3,5,6-tetrafluorophenol	1.167	View
89	pentafluorophenol	1.638	View
90	ethyl-3-hydroxybenzoate	0.478	View
91	4-tert-pentylphenol	1.229	View
92	2,6-dichlorophenol	0.735	View
93	pentachlorophenol	2.049	View
94	3-cyanophenol	-0.064	View
95	4-chloro-3,5-dimethylphenol	1.201	View
96	2,4,6-trichlorophenol	1.410	View
97	2-tert-butylphenol	1.295	View
98	2-isopropylphenol	0.798	View
99	4-chloro-2-isopropyl-5-methylphenol	1.854	View
100	2-ethylphenol	0.160	View
101	2-hydroxybenzylalcohol	-0.954	View
102	2-hydroxybenzaldehyde	0.424	View
103	2-methoxyphenol	-0.510	View
104	3,5-dibromosalicylaldehyde	1.638	View
105	2,6-dimethoxyphenol	-0.598	View
106	2,3,5-trichlorophenol	2.373	View
107	2,3,5,6-tetrachlorophenol	2.222	View
108	2-ethoxyphenol	-0.358	View
109	2-methylphenol	-0.295	View
110	2-bromophenol	0.330	View
111	2-chlorophenol	0.183	View
112	3,4-dimethylphenol	0.122	View
113	3,4-dichlorophenol	1.745	View
114	2,5-dimethylphenol	0.081	View
115	2,4,5-trichlorophenol	2.097	View
116	4-tert-butylphenol	0.914	View
117	4-sec-butylphenol	0.979	View
118	methyl-4-hydroxybenzoate	0.084	View
119	4-isopropylphenol	0.473	View
120	4-hydroxyacetophenone	-0.302	View
121	4-amino-2-nitrophenol	0.879	View
122	2-amino-4-tert-butylphenol	0.366	View
123	2,4-diaminophenol 2HCl	0.127	View
124	5-amino-2-methoxyphenol	0.450	View
125	4-amino-2-cresol	1.307	View
126	6-amino-2,4-dimethylphenol	0.886	View
127	3-aminophenol	-0.524	View
128	2-amino-4-chloro-5-nitrophenol	1.174	View
129	2-hydroxybenzoic acid	-0.512	View
130	2-aminophenol	0.939	View
131	2-amino-4-chlorophenol	0.775	View
132	3-amino-4-hydroxybenzenesulphonic acid	-1.053	View
133	3-hydroxybenzoic acid	-0.814	View
134	2-amino-4-nitrophenol	0.475	View
135	4-hydroxybenzoic acid	-1.021	View
136	4-nitrophenol	1.420	View
137	4-acetamidophenol	-0.820	View
138	4-nitrosophenol	0.654	View
139	4-methyl-2-nitrophenol	0.571	View
140	4-aminophenol	-0.076	View
141	4-methyl-3-nitrophenol	0.740	View
142	3-methyl-4-nitrophenol	1.729	View
143	2-chloromethyl-4-nitrophenol	0.750	View
144	2,6-diiodo-4-nitrophenol	1.712	View
145	2,5-dinitrophenol	0.950	View
146	5-hydroxy-2-nitrobenzaldehyde	0.330	View
147	5-fluoro-2-nitrophenol	1.125	View
148	2,4-dinitrophenol	1.077	View
149	4,6-dinitro-2-methylphenol	1.721	View
150	3-nitrophenol	0.506	View
151	2,6-dinitrophenol	0.539	View
152	3,4-dinitrophenol	0.266	View
153	2,4-chloro-6-nitrophenol	1.745	View
154	2,6-dinitro-4-methylphenol	1.229	View
155	2,6-dichloro-4-nitrophenol	0.632	View
156	2-chloro-4-nitrophenol	1.585	View
157	3-acetamidophenol	-0.155	View
158	2,3-dinitrophenol	0.463	View
159	4-chloro-6-nitro-3-methylphenol	1.638	View
160	2-nitrophenol	0.670	View
161	2,4,6-trinitrophenol	-0.155	View
162	4-chloro-2-nitrophenol	2.053	View
163	salicylhydroxamic acid	0.379	View
164	salicylhydrazide	0.181	View
165	salicylaldoxime	0.253	View
166	2,6-bromo-4-nitrophenol	1.356	View

Bibliography

Cronin, M. T. D.; Schultz, T. W. Structure-toxicity relationships for phenols to Tetrahymena pyriformis. Chemosphere 1996, 32, 1453–1468. https://doi.org/10.1016/0045-6535(96)00054-9
Schultz, T. W.; Lin, D. T.; Wilke, T. S.; Arnold, L. M. Quantitative structure-activity relationships for the Tetrahymena pyriformis population growth endpoint: a mechanism of action approach. In Practical Applications of Quantitative Structure-Activity Relationships (QSAR) in Environmental Chemistry and Toxicology; Karcher, W.; Devillers, J., Eds.; Joint Research Centre; 1990.

10967/20 - QDB Compounds

QsarDB Repository

Cronin, M.T.D.; Schultz, T.W. Structure-toxicity relationships for phenols to Tetrahymena pyriformis. Chemosphere 1996, 32, 8, 1453–1468.

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