35 compounds | Property Activity: Activity against Leishmania donovani
| ID | Name | Activity | Details |
|---|---|---|---|
| 1 | 1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one i | active | View |
| 2 | 1-[(2R)-oxolan-2-yl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one i | inactive | View |
| 3 | 1-[(2R)-oxolan-2-yl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-amine i | inactive | View |
| 4 | 6-(methylsulfanyl)-1-[(2R)-oxolan-2-yl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one i | inactive | View |
| 5 | 6-amino-1-[(2R)-oxolan-2-yl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one i | inactive | View |
| 6 | 1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-(methylsulfanyl)-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one i | active | View |
| 7 | 6-amino-1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one i | inactive | View |
| 8 | 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-(methylsulfanyl)-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one i | active | View |
| 9 | 6-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one i | inactive | View |
| 10 | 6-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one i | inactive | View |
| 11 | 6-amino-1-[(2R,3S,4R,5R)-3,4-bis(benzyloxy)-5-[(benzyloxy)methyl]oxolan-2-yl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one i | active | View |
| 12 | 1-[(2S,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-(methylsulfanyl)-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one i | active | View |
| 13 | 6-amino-1-[(2S,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one i | active | View |
| 14 | 1-[(2S,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-(methylsulfanyl)-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one i | active | View |
| 15 | 6-amino-1-[(2S,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one i | active | View |
| 16 | 1-[(2-hydroxyethoxy)methyl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one i | inactive | View |
| 17 | 2-({4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl}methoxy)ethan-1-ol i | active | View |
| 18 | 2-({4-oxo-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-1-yl}methoxy)ethyl benzoate i | active | View |
| 19 | 1-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one i | active | View |
| 20 | 2-({4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl}methoxy)propane-1,3-diol i | inactive | View |
| 21 | 1-{[(1-amino-3-hydroxypropan-2-yl)oxy]methyl}-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one i | active | View |
| 22 | 6-amino-1-[(2-hydroxyethoxy)methyl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one i | active | View |
| 23 | 4-amino-1-[(2-hydroxyethoxy)methyl]-1H,6H,7H-pyrazolo[3,4-d]pyrimidin-6-one i | active | View |
| 24 | 2-amino-9-[(2-hydroxyethoxy)methyl]-6,9-dihydro-1H-purin-6-one i | inactive | View |
| 25 | 2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-6,9-dihydro-1H-purin-6-one i | inactive | View |
| 26 | (2R,3S,4R,5S)-2-{7-amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl}-5-(hydroxymethyl)oxolane-3,4-diol i | active | View |
| 27 | 3-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one i | active | View |
| 28 | 7-[(2R,3S,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H,4H,5H-pyrrolo[3,2-d]pyrimidin-4-one i | active | View |
| 29 | 6-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H,4H,5H-imidazo[4,5-c]pyridin-4-one i | active | View |
| 30 | 9-[(2S,3S,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-1H-purin-6-one i | active | View |
| 31 | 1H,4H,5H-pyrazolo[3,4-d]pyrimidine-4-thione i | active | View |
| 32 | 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidine-4-thione i | active | View |
| 33 | 3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H,6H,7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one i | active | View |
| 34 | 7-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H,4H-thieno[3,2-d]pyrimidin-4-one i | active | View |
| 35 | 7-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H,4H,7H-pyrrolo[2,3-d]pyrimidin-4-one i | active | View |
Hasan, A.; Tripathi, R. P.; Pratap, R.; Bhakuni, D. S.; Pal, R.; Mishra, A.; Guru, P. Y.; Katiyar, J. C. Studies on nucleosides. Part XX. Synthesis and antileishmanial activity of 4,6-substituted pyrazolo[3,4-d]pyrimidine nucleosides. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry 1989, 28B, 403-409.
Khan, S. I.; Mishra, A.; Guru, P. Y.; Pratap, R.; Bhakuni, D. S. Studies in nucleosides. Part XXV. Synthesis of alicyclic and cyclic nucleosides of 4(5H)-oxopyrazolo[3,4-d]pyrimidine and 4-aminopyrazolo[3,4-d]pyrimidine and their antileishmanial activity. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry 1990, 29B, 40-46.