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10967/169 - QDB Compounds

QsarDB Repository

Oliveira, K. M. G.; Takahata, Y. QSAR Modeling of Nucleosides Against Amastigotes of Leishmania donovani Using Logistic Regression and Classification Tree. QSAR Comb. Sci. 2008, 27, 1020–1027.

35 compounds | Property Activity: Activity against Leishmania donovani

ID Name Activity Details
1 1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one i active View
2 1-[(2R)-oxolan-2-yl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one i inactive View
3 1-[(2R)-oxolan-2-yl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-amine i inactive View
4 6-(methylsulfanyl)-1-[(2R)-oxolan-2-yl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one i inactive View
5 6-amino-1-[(2R)-oxolan-2-yl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one i inactive View
6 1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-(methylsulfanyl)-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one i active View
7 6-amino-1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one i inactive View
8 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-(methylsulfanyl)-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one i active View
9 6-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one i inactive View
10 6-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one i inactive View
11 6-amino-1-[(2R,3S,4R,5R)-3,4-bis(benzyloxy)-5-[(benzyloxy)methyl]oxolan-2-yl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one i active View
12 1-[(2S,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-(methylsulfanyl)-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one i active View
13 6-amino-1-[(2S,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one i active View
14 1-[(2S,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-(methylsulfanyl)-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one i active View
15 6-amino-1-[(2S,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one i active View
16 1-[(2-hydroxyethoxy)methyl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one i inactive View
17 2-({4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl}methoxy)ethan-1-ol i active View
18 2-({4-oxo-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-1-yl}methoxy)ethyl benzoate i active View
19 1-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one i active View
20 2-({4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl}methoxy)propane-1,3-diol i inactive View
21 1-{[(1-amino-3-hydroxypropan-2-yl)oxy]methyl}-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one i active View
22 6-amino-1-[(2-hydroxyethoxy)methyl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one i active View
23 4-amino-1-[(2-hydroxyethoxy)methyl]-1H,6H,7H-pyrazolo[3,4-d]pyrimidin-6-one i active View
24 2-amino-9-[(2-hydroxyethoxy)methyl]-6,9-dihydro-1H-purin-6-one i inactive View
25 2-amino-9-{[(1,3-dihydroxypropan-2-yl)oxy]methyl}-6,9-dihydro-1H-purin-6-one i inactive View
26 (2R,3S,4R,5S)-2-{7-amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl}-5-(hydroxymethyl)oxolane-3,4-diol i active View
27 3-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one i active View
28 7-[(2R,3S,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H,4H,5H-pyrrolo[3,2-d]pyrimidin-4-one i active View
29 6-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H,4H,5H-imidazo[4,5-c]pyridin-4-one i active View
30 9-[(2S,3S,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-1H-purin-6-one i active View
31 1H,4H,5H-pyrazolo[3,4-d]pyrimidine-4-thione i active View
32 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H,4H,5H-pyrazolo[3,4-d]pyrimidine-4-thione i active View
33 3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H,6H,7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one i active View
34 7-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H,4H-thieno[3,2-d]pyrimidin-4-one i active View
35 7-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H,4H,7H-pyrrolo[2,3-d]pyrimidin-4-one i active View

Bibliography

  1. Hasan, A.; Tripathi, R. P.; Pratap, R.; Bhakuni, D. S.; Pal, R.; Mishra, A.; Guru, P. Y.; Katiyar, J. C. Studies on nucleosides. Part XX. Synthesis and antileishmanial activity of 4,6-substituted pyrazolo[3,4-d]pyrimidine nucleosides. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry 1989, 28B, 403-409.

  2. Khan, S. I.; Mishra, A.; Guru, P. Y.; Pratap, R.; Bhakuni, D. S. Studies in nucleosides. Part XXV. Synthesis of alicyclic and cyclic nucleosides of 4(5H)-oxopyrazolo[3,4-d]pyrimidine and 4-aminopyrazolo[3,4-d]pyrimidine and their antileishmanial activity. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry 1990, 29B, 40-46.