Aptula, A.O.; Roberts, D.W.; Cronin, M.T.D.; Schultz, T.W. Chemistry-Toxicity Relationships for the Effects of Di- and Trihydroxybenzenes to Tetrahymena pyriformis. Chem. Res. Toxicol. 2005, 18, 5, 844–854.

38 compounds | Property pIGC50: 40-h Tetrahymena toxicity as log(1/IGC50) [log(L/mmol)]

ID	Name	pIGC50	Ref	Details
1	1,3,5-trihydroxybenzene	-1.26		View
2	2-(2-hydroxyethyl)resorcinol	-0.87		View
3	resorcinol	-0.65		View
4	5-methylresorcinol	-0.39		View
5	4-chlororesorcinol	0.13		View
6	4,6-dichlororesorcinol	0.97		View
7	2,4,6-tribromoresorcinol	1.06		View
8	5-pentylresorcinol	1.31		View
9	2,4-dihydroxybenzophenone	1.37		View
10	4-hexylresorcinol	1.80		View
11	2-nitroresorcinol	0.66		View
12	resorcinol monobenzoate	1.11		View
13	3-methylcatechol	0.28		View
14	4-methylcatechol	0.37		View
15	catechol	0.75		View
16	4-chlorocatechol	1.06		View
17	4-nitrocatechol	1.17		View
18	2,3-dihydroxybenzaldehyde	1.03	[1]	View
19	1,2,3-trihydroxybenzene	0.85		View
20	1,2,4-trihydroxybenzene	0.44		View
21	2,3,4-trihydroxybenzophenone	0.88	[1]	View
22	4,6-dinitro-1,2,3-trihydroxybenzene	1.18	[1]	View
23	hydroquinone	0.47		View
24	methylhydroquinone	1.86		View
25	2,3-dimethylhydroquinone	1.41		View
26	trimethylhydroquinone	1.34		View
27	tetramethylhydroquinone	1.28		View
28	chlorohydroquinone	1.26		View
29	bromohydroquinone	1.68		View
30	tetrachlorohydroquinone	2.11		View
31	tetrafluorohydroquinone	1.84		View
32	phenylhydroquinone	2.01		View
33	2,5-dihydroxybenzaldehyde	0.71	[1]	View
34	2,5-dichlorohydroquinone	1.81	[1]	View
35	tetrachlorocatechol	1.70		View
36	tetrabromocatechol	0.98		View
37	methoxyhydroquinone	2.20		View
38	2,3-dicyanohydroquinone	-0.44		View

Bibliography

Aptula, A. O.; Roberts, D. W.; Cronin, M. T. D.; Schultz, T. W. Chemistry-Toxicity Relationships for the Effects of Di- and Trihydroxybenzenes to Tetrahymena pyriformis. Chem. Res. Toxicol. 2005, 18, 844–854. https://doi.org/10.1021/tx049666n
Schultz, T. W.; Sinks, G. D.; Cronin, M. T. D. Identification of Mechanisms of Toxic Action of Phenols to Tetrahymena pyriformis from Molecular Descriptors. In Quantitative Structure-Activity Relationships in Environmental Sciences; Chen, F.; Schüürmann, G., Eds.; SETAC Press; 1997.
Netzeva, T. I.; Aptula, A. O.; Chaudary, S. H.; Duffy, J. C.; Schultz, T. W.; Schüürmann, G.; Cronin, M. T. D. Structure-Activity Relationships for the Toxicity of Substituted Poly-hydroxylated Benzenes to Tetrahymena pyriformis: Influence of Free Radical Formation. QSAR Comb. Sci. 2003, 22, 575–582. https://doi.org/10.1002/qsar.200330816
Schultz, T. W. TETRATOX: Tetrahymena pyriformis population growth impairment endpoint - a surrogate for fish lethality. Toxicol. Mech. Meth. 1997, 7, 289–309. https://doi.org/10.1080/105172397243079