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Franke, R.; Gruska, A.; Giuliani, A.; Benigni, R. Prediction of rodent carcinogenicity of aromatic amines: a quantitative structure-activity relationships model. Carcinogenesis 2001, 22, 1561–1571.

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Franke, R.; Gruska, A.; Giuliani, A.; Benigni, R. Prediction of rodent carcinogenicity of aromatic amines: a quantitative structure-activity relationships model. Carcinogenesis 2001, 22, 1561–1571.

QDB archive DOI: 10.15152/QDB.142   DOWNLOAD

QsarDB content

Property Carcinogenicity: Class: C - Carcinogenic, nC -non-Carcinogenic

Eq.5: Carcinogenic class of aromatic amines

Regression model (classification)   QMRF

Open in:QDB Explorer QDB Predictor

Name Type n Accuracy
Training set. training 64 0.922

Property Potency: Carcinogenic potency as log(MW/TD50) [log((mol/kg)/TD50)]

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When using this QDB archive, please cite (see details) it together with the original article:

  • Garcia-Sosa, A. T. Data for: Prediction of rodent carcinogenicity of aromatic amines: a quantitative structure-activity relationships model. QsarDB repository, QDB.142. 2015. http://dx.doi.org/10.15152/QDB.142

  • Franke, R.; Gruska, A.; Giuliani, A.; Benigni, R. Prediction of rodent carcinogenicity of aromatic amines: a quantitative structure-activity relationships model. Carcinogenesis 2001, 22, 1561–1571. http://dx.doi.org/10.1093/carcin/22.9.1561

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dc.date.accessioned 2015-03-23T12:23:10Z
dc.date.available 2015-03-23T12:23:10Z
dc.date.issued 2015-03-23 *
dc.identifier.uri http://hdl.handle.net/10967/142
dc.identifier.uri http://dx.doi.org/10.15152/QDB.142
dc.description.abstract The aromatic amines are widely used industrial chemicals and can be found in tobacco smoke as well as in products generated during cooking. In a previous study, we established quantitative structure–activity relationship (QSAR) models linking the carcinogenic potency of non- heterocyclic carcinogenic aromatic amines to a series of molecular determinants. We also found that QSAR models for carcinogenic potency were inadequate in describing the difference between carcinogenic and non-carcinogenic amines [Benigni,R., Giuliani,A., Franke,R. and Gruska,A. (2000) Chem. Rev., 100, 3697–3714]. In this paper, we derived specific QSAR models for separating active from inactive amines. It appeared that hydrophobicity (as measured by the octanol/water partition coefficient, logP) played a major role in modulating the potency of the carcinogens, whereas mainly electronic (reactivity) and steric characteristics separated the carcinogens from the non-carcinogens. Interestingly, a similar pattern was previously demonstrated by us regarding their mutagenic activity [Benigni,R., Passerini,L., Gallo,G., Giorgi,F. and Cotta-Ramusino,M. (1998) Environ. Mol. Mutagen., 32, 75–83]. Based on the QSAR models found, the molecular determinants of the mechanisms of action of aromatic amines are discussed in detail. The QSAR models obtained can be used directly for estimating the carcinogenicity of other non-heterocyclic aromatic amines for which experi- mental data are not available. With the QSARs in Benigni et al. (2000) and the present results, a two-step prediction of carcinogenicity of aromatic amines is possible: (i) step 1, yes/no activity from the discriminant functions; and (ii) step 2, if the answer from step 1 is yes then prediction of the degree of potency from the equations in Benigni et al. (2000). Thus, QSAR models can contribute to the following: the direct synthesis of safer chemicals; the estimation of the risk posed by amines present in the environment; setting priorities for further experimentation, thus also reducing the use of experimental animals. Whereas the quality of in vivo experimental data is often questioned, the robustness and intepretability of the present results strongly support the reliability of the rodent carcino- genicity assay.
dc.publisher Alfonso T. Garcia-Sosa
dc.rights Attribution-ShareAlike 4.0 International
dc.rights.uri http://creativecommons.org/licenses/by-sa/4.0/
dc.title Franke, R.; Gruska, A.; Giuliani, A.; Benigni, R. Prediction of rodent carcinogenicity of aromatic amines: a quantitative structure-activity relationships model. Carcinogenesis 2001, 22, 1561–1571.
qdb.property.endpoint 4. Human health effects 4.12. Carcinogenicity en_US
qdb.property.species Rattus norvegicus (Rat) en_US
qdb.descriptor.application MOPAC en_US
qdb.descriptor.application Sterimol en_US
bibtex.entry article en_US
bibtex.entry.author Franke, R.
bibtex.entry.author Gruska, A.
bibtex.entry.author Giuliani, A.
bibtex.entry.author Benigni, R.
bibtex.entry.doi 10.1093/carcin/22.9.1561 en_US
bibtex.entry.journal Carcinogenesis en_US
bibtex.entry.month Sep
bibtex.entry.number 9 en_US
bibtex.entry.pages 1561–1571 en_US
bibtex.entry.title Prediction of rodent carcinogenicity of aromatic amines: a quantitative structure-activity relationships model en_US
bibtex.entry.volume 22 en_US
bibtex.entry.year 2001
qdb.model.type Regression model (classification) en_US
qdb.model.qmrf Eq.5=Q13-412-0066


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