Zukić, S.; Osmanović, A.; Harej, A.; Kraljević Pavelić, S.; Špirtović-Halilović, S.; Veljović, E.; Roca, S.; Trifunović, S.; Završnik, D.; Maran, U. Data driven modelling of substituted pyrimidine and uracil-based derivatives validated with newly synthesized and antiproliferative evaluated compounds. Int. J. Mol. Sci. 2024, 25, 9390

39 compounds | Property pIC50: Antiproliferative activity [-log(uM)] i

ID	Name	pIC50	Ref	Details
T01	CHEMBL3288100	4.53	[1]	View
T02	CHEMBL3288101	4.77	[1]	View
T04	CHEMBL3288099	5.46	[1]	View
T05	CHEMBL3288102	6.52	[1]	View
T06	CHEMBL3758886	4.1	[2]	View
T07	CHEMBL3758430	4.12	[2]	View
T08	CHEMBL3759126	4.15	[2]	View
T10	CHEMBL3759620	4.19	[2]	View
T11	CHEMBL3758366	4.2	[2]	View
T12	CHEMBL3759428	4.23	[2]	View
T14	CHEMBL3759340	4.28	[2]	View
T15	CHEMBL3759692	4.32	[2]	View
T16	CHEMBL3758416	4.33	[2]	View
T17	CHEMBL3759421	4.49	[2]	View
T18	CHEMBL3760087	4.51	[2]	View
T20	CHEMBL3758189	5.11	[2]	View
T21	CHEMBL241981	4.22	[3]	View
T22	CHEMBL266328	4.25	[3]	View
T24	CHEMBL244983	4.46	[3]	View
T25	CHEMBL397657	4.7	[3]	View
T26	CHEMBL397658	4.7	[3]	View
T28	CHEMBL388691	4.77	[3]	View
T29	CHEMBL244768	4.8	[3]	View
T30	CHEMBL244767	4.8	[3]	View
T32	CHEMBL245204	4.85	[3]	View
T33	CHEMBL245206	4.85	[3]	View
T34	CHEMBL443227	4.85	[3]	View
T36	CHEMBL397899	4.96	[3]	View
T37	CHEMBL244984	5.1	[3]	View
T38	CHEMBL389565	5.4	[3]	View
T39	CHEMBL244769	5.52	[3]	View
V03	CHEMBL1835794	5.43	[1]	View
V09	CHEMBL3759268	4.17	[2]	View
V13	CHEMBL3759720	4.27	[2]	View
V19	CHEMBL3758473	4.52	[2]	View
V23	CHEMBL388690	4.42	[3]	View
V27	CHEMBL245205	4.77	[3]	View
V31	CHEMBL397659	4.85	[3]	View
V35	CHEMBL390861	4.92	[3]	View

Bibliography

Gazivoda Kraljević, T.; Ilić, N.; Stepanić, V.; Sappe, L.; Petranović, J.; Kraljević Pavelić, S.; Raić-Malić, S. Synthesis and in vitro antiproliferative evaluation of novel N-alkylated 6-isobutyl- and propyl pyrimidine derivatives. Bioorganic & Medicinal Chemistry Letters 2014, 24, 2913–2917. https://doi.org/10.1016/j.bmcl.2014.04.079
Meščić, A.; Harej, A.; Klobučar, M.; Glavač, D.; Cetina, M.; Pavelić, S. K.; Raić-Malić, S. Discovery of New Acid Ceramidase-Targeted Acyclic 5-Alkynyl and 5-Heteroaryl Uracil Nucleosides. ACS Medicinal Chemistry Letters 2015, 6, 1150–1155. https://doi.org/10.1021/acsmedchemlett.5b00298
Gazivoda, T.; Šokčević, M.; Kralj, M.; Šuman, L.; Pavelić, K.; De Clercq, E.; Andrei, G.; Snoeck, R.; Balzarini, J.; Mintas, M.; Raić-Malić, S. Synthesis and Antiviral and Cytostatic Evaluations of the New C-5 Substituted Pyrimidine and Furo[2,3-d]pyrimidine 4‘,5‘-Didehydro-L-ascorbic Acid Derivatives. Journal of Medicinal Chemistry 2007, 50, 4105–4112. https://doi.org/10.1021/jm070324z