ID: | 8 | |
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Name: | Chlorzolamide | |
Description: | ||
Labels: | ||
CAS: | ||
InChi Code: | InChI=1S/C8H6ClN3O2S2/c9-6-4-2-1-3-5(6)7-11-12-8(15-7)16(10,13)14/h1-4H,(H2,10,13,14) |
perm: Corneal permeability [cm/s]
Value | Source or prediction |
---|---|
1.8E-5 |
Duffel, M. W.; Ing, I. S.; Segarra, T. M.; Dixson, J. A.; Barfknecht, C. F.; Schoenwald, R. D. N-Substituted sulfonamide carbonic anhydrase inhibitors with topical effects on intraocular pressure. Journal of Medicinal Chemistry 1986, 29, 1488–1494. https://doi.org/10.1021/jm00158a028 |
logPapp: The logarithm of the corneal permeability [log(cm/s)]
Value | Source or prediction |
---|---|
-4.74 |
Duffel, M. W.; Ing, I. S.; Segarra, T. M.; Dixson, J. A.; Barfknecht, C. F.; Schoenwald, R. D. N-Substituted sulfonamide carbonic anhydrase inhibitors with topical effects on intraocular pressure. Journal of Medicinal Chemistry 1986, 29, 1488–1494. https://doi.org/10.1021/jm00158a028 |
-4.82 |
Eq.3b: Model for drug-like compounds at pH 7.4 (Trainig set) |
-4.96 |
Eq.4b: Model for drug-like compounds at pH 8.0 (Trainig set) |