Kidron, H.; Vellonen, K.-S.; del Amo, E. M.; Tissari, A.; Urtti, A. Prediction of the Corneal Permeability of Drug-Like Compounds. Pharm. Res. 2010, 27, 1398–1407.
Compound
| ID: | 68 | |
|---|---|---|
| Name: | Betaxolol | |
| Description: | ||
| Labels: | ||
| CAS: | ||
| InChi Code: | InChI=1S/C18H29NO3/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3 |
Properties
perm: Corneal permeability [cm/s]
| Value | Source or prediction |
|---|---|
| 6.0E-5 |
Rusinko, A.; Hellberg, M. R.; May, J. A.; Owen, G. R. Use of mdck cell line to predict corneal penetration of drugs. 2008. |
logPapp: The logarithm of the corneal permeability [log(cm/s)]
| Value | Source or prediction |
|---|---|
| -4.22 |
Rusinko, A.; Hellberg, M. R.; May, J. A.; Owen, G. R. Use of mdck cell line to predict corneal penetration of drugs. 2008. |
| -4.72 |
Eq.3b: Model for drug-like compounds at pH 7.4 (Validation set) |
| -4.61 |
Eq.4b: Model for drug-like compounds at pH 8.0 (Validation set) |
Links to External Resources
| Link | Resource description |
|---|---|
| DTXSID2022674 | US EPA CompTox Dashboard |