Kidron, H.; Vellonen, K.-S.; del Amo, E. M.; Tissari, A.; Urtti, A. Prediction of the Corneal Permeability of Drug-Like Compounds. Pharm. Res. 2010, 27, 1398–1407.
Compound
| ID: | 62 | |
|---|---|---|
| Name: | Lomefloxacin | |
| Description: | ||
| Labels: | ||
| CAS: | ||
| InChi Code: | InChI=1S/C17H19F2N3O3/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25) |
Properties
perm: Corneal permeability [cm/s]
| Value | Source or prediction |
|---|---|
| 3.5E-6 |
Rusinko, A.; Hellberg, M. R.; May, J. A.; Owen, G. R. Use of mdck cell line to predict corneal penetration of drugs. 2008. |
logPapp: The logarithm of the corneal permeability [log(cm/s)]
| Value | Source or prediction |
|---|---|
| -5.46 |
Rusinko, A.; Hellberg, M. R.; May, J. A.; Owen, G. R. Use of mdck cell line to predict corneal penetration of drugs. 2008. |
| -5.25 |
Eq.3b: Model for drug-like compounds at pH 7.4 (Validation set) |
| -5.3 |
Eq.4b: Model for drug-like compounds at pH 8.0 (Validation set) |
Links to External Resources
| Link | Resource description |
|---|---|
| DTXSID4040680 | US EPA CompTox Dashboard |