Kidron, H.; Vellonen, K.-S.; del Amo, E. M.; Tissari, A.; Urtti, A. Prediction of the Corneal Permeability of Drug-Like Compounds. Pharm. Res. 2010, 27, 1398–1407.
Compound
| ID: | 61 | |
|---|---|---|
| Name: | Gatifloxacin | |
| Description: | ||
| Labels: | ||
| CAS: | ||
| InChi Code: | InChI=1S/C19H22FN3O4/c1-10-8-22(6-5-21-10)16-14(20)7-12-15(18(16)27-2)23(11-3-4-11)9-13(17(12)24)19(25)26/h7,9-11,21H,3-6,8H2,1-2H3,(H,25,26) |
Properties
perm: Corneal permeability [cm/s]
| Value | Source or prediction |
|---|---|
| 2.5E-6 |
Rusinko, A.; Hellberg, M. R.; May, J. A.; Owen, G. R. Use of mdck cell line to predict corneal penetration of drugs. 2008. |
logPapp: The logarithm of the corneal permeability [log(cm/s)]
| Value | Source or prediction |
|---|---|
| -5.6 |
Rusinko, A.; Hellberg, M. R.; May, J. A.; Owen, G. R. Use of mdck cell line to predict corneal penetration of drugs. 2008. |
| -5.71 |
Eq.3b: Model for drug-like compounds at pH 7.4 (Validation set) |
| -5.72 |
Eq.4b: Model for drug-like compounds at pH 8.0 (Validation set) |
Links to External Resources
| Link | Resource description |
|---|---|
| DTXSID5045704 | US EPA CompTox Dashboard |