Kidron, H.; Vellonen, K.-S.; del Amo, E. M.; Tissari, A.; Urtti, A. Prediction of the Corneal Permeability of Drug-Like Compounds. Pharm. Res. 2010, 27, 1398–1407.
Compound
| ID: | 60 | |
|---|---|---|
| Name: | Levofloxacin | |
| Description: | ||
| Labels: | ||
| CAS: | ||
| InChi Code: | InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)/t10-/m0/s1 |
Properties
perm: Corneal permeability [cm/s]
| Value | Source or prediction |
|---|---|
| 2.9E-6 |
Rusinko, A.; Hellberg, M. R.; May, J. A.; Owen, G. R. Use of mdck cell line to predict corneal penetration of drugs. 2008. |
logPapp: The logarithm of the corneal permeability [log(cm/s)]
| Value | Source or prediction |
|---|---|
| -5.54 |
Rusinko, A.; Hellberg, M. R.; May, J. A.; Owen, G. R. Use of mdck cell line to predict corneal penetration of drugs. 2008. |
| -5.53 |
Eq.3b: Model for drug-like compounds at pH 7.4 (Validation set) |
| -5.63 |
Eq.4b: Model for drug-like compounds at pH 8.0 (Validation set) |
Links to External Resources
| Link | Resource description |
|---|---|
| DTXSID0041060 | US EPA CompTox Dashboard |