Kidron, H.; Vellonen, K.-S.; del Amo, E. M.; Tissari, A.; Urtti, A. Prediction of the Corneal Permeability of Drug-Like Compounds. Pharm. Res. 2010, 27, 1398–1407.
Compound
| ID: | 39 | |
|---|---|---|
| Name: | 4-chlorobenzene-1-sulfonamide | |
| Description: | ||
| Labels: | ||
| CAS: | ||
| InChi Code: | InChI=1S/C6H6ClNO2S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4H,(H2,8,9,10) |
Properties
perm: Corneal permeability [cm/s]
| Value | Source or prediction |
|---|---|
| 5.5E-5 |
Maren, T. H.; Jankowska, L.; Sanyal, G.; Edelhauser, H. F. The transcorneal permeability of sulfonamide carbonic anhydrase inhibitors and their effect on aqueous humor secretion. Experimental Eye Research 1983, 36, 457–479. https://doi.org/10.1016/0014-4835(83)90041-6 |
logPapp: The logarithm of the corneal permeability [log(cm/s)]
| Value | Source or prediction |
|---|---|
| -4.26 |
Maren, T. H.; Jankowska, L.; Sanyal, G.; Edelhauser, H. F. The transcorneal permeability of sulfonamide carbonic anhydrase inhibitors and their effect on aqueous humor secretion. Experimental Eye Research 1983, 36, 457–479. https://doi.org/10.1016/0014-4835(83)90041-6 |
| -4.57 |
Eq.3b: Model for drug-like compounds at pH 7.4 (Trainig set) |
| -4.62 |
Eq.4b: Model for drug-like compounds at pH 8.0 (Trainig set) |
Links to External Resources
| Link | Resource description |
|---|---|
| DTXSID6052661 | US EPA CompTox Dashboard |