Kidron, H.; Vellonen, K.-S.; del Amo, E. M.; Tissari, A.; Urtti, A. Prediction of the Corneal Permeability of Drug-Like Compounds. Pharm. Res. 2010, 27, 1398–1407.
Compound
| ID: | 38 | |
|---|---|---|
| Name: | 1[(N-methylamino) sulfonyl]-4-chloro-benzene | |
| Description: | ||
| Labels: | ||
| CAS: | ||
| InChi Code: | InChI=1S/C7H8ClNO2S/c1-9-12(10,11)7-4-2-6(8)3-5-7/h2-5,9H,1H3 |
Properties
perm: Corneal permeability [cm/s]
| Value | Source or prediction |
|---|---|
| 6.5E-5 |
Maren, T. H.; Jankowska, L.; Sanyal, G.; Edelhauser, H. F. The transcorneal permeability of sulfonamide carbonic anhydrase inhibitors and their effect on aqueous humor secretion. Experimental Eye Research 1983, 36, 457–479. https://doi.org/10.1016/0014-4835(83)90041-6 |
logPapp: The logarithm of the corneal permeability [log(cm/s)]
| Value | Source or prediction |
|---|---|
| -4.19 |
Maren, T. H.; Jankowska, L.; Sanyal, G.; Edelhauser, H. F. The transcorneal permeability of sulfonamide carbonic anhydrase inhibitors and their effect on aqueous humor secretion. Experimental Eye Research 1983, 36, 457–479. https://doi.org/10.1016/0014-4835(83)90041-6 |
| -4.09 |
Eq.3b: Model for drug-like compounds at pH 7.4 (Trainig set) |
| -4.17 |
Eq.4b: Model for drug-like compounds at pH 8.0 (Trainig set) |