Kidron, H.; Vellonen, K.-S.; del Amo, E. M.; Tissari, A.; Urtti, A. Prediction of the Corneal Permeability of Drug-Like Compounds. Pharm. Res. 2010, 27, 1398–1407.
Compound
| ID: | 21 | |
|---|---|---|
| Name: | 6-acetamido-2-benzo-thiazolesulfonamide | |
| Description: | ||
| Labels: | ||
| CAS: | ||
| InChi Code: | InChI=1S/C9H9N3O3S2/c1-5(13)11-6-2-3-7-8(4-6)16-9(12-7)17(10,14)15/h2-4H,1H3,(H,11,13)(H2,10,14,15) |
Properties
perm: Corneal permeability [cm/s]
| Value | Source or prediction |
|---|---|
| 4.7E-6 |
Schoenwald, R. D.; Houseman, J. A. Disposition of cyclophosphamide in the rabbit and human cornea. Biopharmaceutics & Drug Disposition 1982, 3, 231–241. https://doi.org/10.1002/bdd.2510030306 |
logPapp: The logarithm of the corneal permeability [log(cm/s)]
| Value | Source or prediction |
|---|---|
| -5.33 |
Schoenwald, R. D.; Houseman, J. A. Disposition of cyclophosphamide in the rabbit and human cornea. Biopharmaceutics & Drug Disposition 1982, 3, 231–241. https://doi.org/10.1002/bdd.2510030306 |
| -5.31 |
Eq.3b: Model for drug-like compounds at pH 7.4 (Trainig set) |
| -5.34 |
Eq.4b: Model for drug-like compounds at pH 8.0 (Trainig set) |