Kidron, H.; Vellonen, K.-S.; del Amo, E. M.; Tissari, A.; Urtti, A. Prediction of the Corneal Permeability of Drug-Like Compounds. Pharm. Res. 2010, 27, 1398–1407.
Compound
| ID: | 11 | |
|---|---|---|
| Name: | Cyclophosphamide | |
| Description: | ||
| Labels: | ||
| CAS: | ||
| InChi Code: | InChI=1S/C7H15Cl2N2O2P/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14/h1-7H2,(H,10,12) |
Properties
perm: Corneal permeability [cm/s]
| Value | Source or prediction |
|---|---|
| 1.1E-5 |
Chiang, C.; Schoenwald, R.; Huang, H. Corneal permeability of adrenergic agents potentially useful in glaucoma. J Taiwan Pharmaceut Assoc 1986, 38, 67–84. |
logPapp: The logarithm of the corneal permeability [log(cm/s)]
| Value | Source or prediction |
|---|---|
| -4.96 |
Chiang, C.; Schoenwald, R.; Huang, H. Corneal permeability of adrenergic agents potentially useful in glaucoma. J Taiwan Pharmaceut Assoc 1986, 38, 67–84. |
| -4.74 |
Eq.3b: Model for drug-like compounds at pH 7.4 (Trainig set) |
| -4.79 |
Eq.4b: Model for drug-like compounds at pH 8.0 (Trainig set) |
Links to External Resources
| Link | Resource description |
|---|---|
| DTXSID5020364 | US EPA CompTox Dashboard |