40 compounds | Property pKd: Binding affinity [log(mol)]
| ID | Name | pKd | Details |
|---|---|---|---|
| 1a | 4-{2-[(4-hydroxy-6-methylpyrimidin-2-yl)sulfanyl]acetyl}benzene-1-sulfonamide | 7.17587 | View |
| 1b | 4-{2-[(5-benzyl-4-hydroxy-6-methylpyrimidin-2-yl)sulfanyl]acetyl}benzene-1-sulfonamide | 7.60206 | View |
| 1c | 4-{2-[(4-hydroxy-6-propylpyrimidin-2-yl)sulfanyl]acetyl}benzene-1-sulfonamide | 7.07935 | View |
| 1d | 4-{2-[(4-tert-butyl-6-hydroxypyrimidin-2-yl)sulfanyl]acetyl}benzene-1-sulfonamide | 7.5376 | View |
| 1e | ethyl 4-hydroxy-2-{[2-oxo-2-(4-sulfamoylphenyl)ethyl]sulfanyl}pyrimidine-5-carboxylate | 7.74473 | View |
| 1f | 4-{2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetyl}benzene-1-sulfonamide | 7.47756 | View |
| 1g | 4-{2-[(5-ethylpyrimidin-2-yl)sulfanyl]acetyl}benzene-1-sulfonamide | 7.90309 | View |
| 1h | 4-{2-[(5-propylpyrimidin-2-yl)sulfanyl]acetyl}benzene-1-sulfonamide | 7.90309 | View |
| 1i | 4-{2-[(5-butylpyrimidin-2-yl)sulfanyl]acetyl}benzene-1-sulfonamide | 7.84466 | View |
| 1j | 4-[2-(pyrimidin-2-ylsulfanyl)acetyl]benzene-1-sulfonamide | 7.77728 | View |
| 2a | 2-chloro-4-{2-[(4-hydroxy-6-methylpyrimidin-2-yl)sulfanyl]acetyl}benzene-1-sulfonamide | 7.67162 | View |
| 2b | 4-{2-[(5-benzyl-4-hydroxy-6-methylpyrimidin-2-yl)sulfanyl]acetyl}-2-chlorobenzene-1-sulfonamide | 7.17587 | View |
| 2c | 2-chloro-4-{2-[(4-hydroxy-6-propylpyrimidin-2-yl)sulfanyl]acetyl}benzene-1-sulfonamide | 6.95468 | View |
| 2d | 4-{2-[(4-tert-butyl-6-hydroxypyrimidin-2-yl)sulfanyl]acetyl}-2-chlorobenzene-1-sulfonamide | 7.39794 | View |
| 2e | ethyl 2-{[2-(3-chloro-4-sulfamoylphenyl)-2-oxoethyl]sulfanyl}-4-hydroxypyrimidine-5-carboxylate | 7.69897 | View |
| 2f | 2-chloro-4-{2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetyl}benzene-1-sulfonamide | 7.77728 | View |
| 2g | 2-chloro-4-{2-[(5-ethylpyrimidin-2-yl)sulfanyl]acetyl}benzene-1-sulfonamide | 8.1463 | View |
| 2h | 2-chloro-4-{2-[(5-propylpyrimidin-2-yl)sulfanyl]acetyl}benzene-1-sulfonamide | 8.1463 | View |
| 2i | 4-{2-[(5-butylpyrimidin-2-yl)sulfanyl]acetyl}-2-chlorobenzene-1-sulfonamide | 8.11407 | View |
| 2j | 2-chloro-4-[2-(pyrimidin-2-ylsulfanyl)acetyl]benzene-1-sulfonamide | 7.95468 | View |
| 3a | 3-{2-[(4-hydroxy-6-methylpyrimidin-2-yl)sulfanyl]acetyl}benzene-1-sulfonamide | 5.90309 | View |
| 3b | 3-{2-[(5-benzyl-4-hydroxy-6-methylpyrimidin-2-yl)sulfanyl]acetyl}benzene-1-sulfonamide | 5.95468 | View |
| 3c | 3-{2-[(4-hydroxy-6-propylpyrimidin-2-yl)sulfanyl]acetyl}benzene-1-sulfonamide | 6.30103 | View |
| 3d | 3-{2-[(4-tert-butyl-6-hydroxypyrimidin-2-yl)sulfanyl]acetyl}benzene-1-sulfonamide | 6.30103 | View |
| 3e | ethyl 4-hydroxy-2-{[2-oxo-2-(3-sulfamoylphenyl)ethyl]sulfanyl}pyrimidine-5-carboxylate | 6.17587 | View |
| 3f | 3-{2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetyl}benzene-1-sulfonamide | 6 | View |
| 3g | 3-{2-[(5-ethylpyrimidin-2-yl)sulfanyl]acetyl}benzene-1-sulfonamide | 6.17587 | View |
| 3h | 3-{2-[(5-propylpyrimidin-2-yl)sulfanyl]acetyl}benzene-1-sulfonamide | 6.25493 | View |
| 3i | 3-{2-[(5-butylpyrimidin-2-yl)sulfanyl]acetyl}benzene-1-sulfonamide | 6.50446 | View |
| 3j | 3-[2-(pyrimidin-2-ylsulfanyl)acetyl]benzene-1-sulfonamide | 5.95468 | View |
| 4a | 2-chloro-5-{2-[(4-hydroxy-6-methylpyrimidin-2-yl)sulfanyl]acetyl}benzene-1-sulfonamide | 6.69897 | View |
| 4b | 5-{2-[(5-benzyl-4-hydroxy-6-methylpyrimidin-2-yl)sulfanyl]acetyl}-2-chlorobenzene-1-sulfonamide | 7.47756 | View |
| 4c | 2-chloro-5-{2-[(4-hydroxy-6-propylpyrimidin-2-yl)sulfanyl]acetyl}benzene-1-sulfonamide | 7.17587 | View |
| 4d | 5-{2-[(4-tert-butyl-6-hydroxypyrimidin-2-yl)sulfanyl]acetyl}-2-chlorobenzene-1-sulfonamide | 7.30103 | View |
| 4e | ethyl 2-{[2-(4-chloro-3-sulfamoylphenyl)-2-oxoethyl]sulfanyl}-4-hydroxypyrimidine-5-carboxylate | 7.30103 | View |
| 4f | 2-chloro-5-{2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetyl}benzene-1-sulfonamide | 6.65365 | View |
| 4g | 2-chloro-5-{2-[(5-ethylpyrimidin-2-yl)sulfanyl]acetyl}benzene-1-sulfonamide | 6.84466 | View |
| 4h | 2-chloro-5-{2-[(5-propylpyrimidin-2-yl)sulfanyl]acetyl}benzene-1-sulfonamide | 7 | View |
| 4i | 5-{2-[(5-butylpyrimidin-2-yl)sulfanyl]acetyl}-2-chlorobenzene-1-sulfonamide | 7.17587 | View |
| 4j | 2-chloro-5-[2-(pyrimidin-2-ylsulfanyl)acetyl]benzene-1-sulfonamide | 6.47756 | View |
Čapkauskaitė, E.; Zubrienė, A.; Smirnov, A.; Torresan, J.; Kišonaitė, M.; Kazokaitė, J.; Gylytė, J.; Michailovienė, V.; Jogaitė, V.; Manakova, E.; al, e. Benzenesulfonamides with pyrimidine moiety as inhibitors of human carbonic anhydrases I, II, VI, VII, XII, and XIII. Bioorganic & Medicinal Chemistry 2013, 21, 6937–6947. http://dx.doi.org/10.1016/j.bmc.2013.09.029