REPOSITORY ABOUT GUIDELINES CITING BLOG

10967/149 - QDB Compounds

QsarDB Repository

Narasimhan, B.; Ansari, A.M.; Singh, N.; Mourya, V.; Dhakee, A.S. A QSAR Approach for the Prediction of Stability of Benzoglycolamide Ester Prodrugs. Chem. Pharm. Bull. 2006, 54, 1067–1071.

37 compounds | Property logK: Hydrolytic rate constant as logK

ID Name logK Details
1 carbamoylmethyl benzoate i -1.84 View
2 (methylcarbamoyl)methyl benzoate i -1.93 View
3 (ethylcarbamoyl)methyl benzoate i -1.82 View
4 (propylcarbamoyl)methyl benzoate i -1.72 View
5 [(propan-2-yl)carbamoyl]methyl benzoate i -1.76 View
6 (tert-butylcarbamoyl)methyl benzoate i -1.71 View
7 [(carbamoylmethyl)carbamoyl]methyl benzoate i -1.98 View
8 [(1-carbamoylethyl)carbamoyl]methyl benzoate i -1.81 View
9 {[1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl]carbamoyl}methyl benzoate i -2 View
10 [ethyl(methyl)carbamoyl]methyl benzoate i -1.28 View
11 (diethylcarbamoyl)methyl benzoate i -1.21 View
12 (dipropylcarbamoyl)methyl benzoate i -1.15 View
13 [bis(prop-2-en-1-yl)carbamoyl]methyl benzoate i -1.26 View
14 (dibutylcarbamoyl)methyl benzoate i -1.05 View
15 [bis(2-methylpropyl)carbamoyl]methyl benzoate i -1.01 View
16 [(carbamoylmethyl)(methyl)carbamoyl]methyl benzoate i -1.37 View
17 [(2-hydroxyethyl)(methyl)carbamoyl]methyl benzoate i -1.21 View
18 [ethyl(2-hydroxyethyl)carbamoyl]methyl benzoate i -1.21 View
19 [bis(2-hydroxypropyl)carbamoyl]methyl benzoate i -1.13 View
20 [bis(2-methoxyethyl)carbamoyl]methyl benzoate i -1.13 View
21 ethyl 2-[2-(benzoyloxy)-N-methylacetamido]acetate i -1.19 View
22 [hexyl(methyl)carbamoyl]methyl benzoate i -1.2 View
23 (dihexylcarbamoyl)methyl benzoate i -1.06 View
24 {[2-(dimethylamino)ethyl](methyl)carbamoyl}methyl benzoate i -1.25 View
25 [(pyrrolidin-1-yl)carbamoyl]methyl benzoate i -1.24 View
26 [(piperidin-1-yl)carbamoyl]methyl benzoate i -1.25 View
27 [(azepan-1-yl)carbamoyl]methyl benzoate i -1.09 View
28 [(morpholin-4-yl)carbamoyl]methyl benzoate i -1.27 View
29 [(2-ethylpiperidin-1-yl)carbamoyl]methyl benzoate i -1.08 View
30 [(2,6-dimethylpiperidin-1-yl)carbamoyl]methyl benzoate i -1 View
31 [(4-hydroxypiperidin-1-yl)carbamoyl]methyl benzoate i -1.23 View
32 [(4-methylpiperazin-1-yl)carbamoyl]methyl benzoate hydrochloride i -1.33 View
33 {[4-(2-hydroxyethyl)piperazin-1-yl]carbamoyl}methyl benzoate hydrochloride i -1.35 View
34 1-[2-(benzoyloxy)acetamido]azetidine-2-carboxylic acid i -1.39 View
35 1-[2-(benzoyloxy)acetamido]pyrrolidine-2-carboxylic acid i -1.29 View
36 methyl 1-[2-(benzoyloxy)acetamido]pyrrolidine-2-carboxylate i -1.21 View
37 [(2-carbamoylpyrrolidin-1-yl)carbamoyl]methyl benzoate i -1.41 View

Bibliography

  1. Nielsenw, N. M.; Bundgaard, H. Glycolamide esters as biolabile prodrugs of carboxylic acid agents: Synthesis, stability, bioconversion, and physicochemical properties. Journal of Pharmaceutical Sciences 1988, 77, 285–298. http://dx.doi.org/10.1002/jps.2600770402