Abstract: A diverse series of amides were evaluated for aquatic toxicity (IGC(50)) assessed in the Tetrahymena pyriformis population growth impairment assay and for reactivity (EC(50)) with the model soft nucleophile thiol in the form of the cysteine residue of the tripeptide glutathione. All alkylamides along with some halo-substituted amides are well predicted by the ...

Abstract: A series of eleven nitrogen-containing heterocyclic compounds, which may be potentially associated with aqueous effluents from coal conversion technologies, were examined to determine the relationships between theirn-octanol/H2O partition coefficients, molecular weights, boiling points, and their toxicity monitored as reproduction impairment toTetrahymena ...

Abstract: Thirteen dinitrogen-containing cyclic compounds were examined to determine the relationship between selected structural and physicochemical parameters and impairment to population growth of the common ciliateTetrahymena pyriformis. Under static conditions all compounds tested are persistent in aqueous solution. Both an increase in methyl substitution and an ...

Abstract: Toxicity (1/IGC(50)) in the Tetrahymena population growth assay and reactivity (1/EC(50)) with the thiol moiety of the cysteine residue of glutathione (GSH) were determined for a series of aromatic isothiocyanates (NCSs). Comparison of both toxicity and reactivity between the analogues revealed that derivatives with the NCS-moiety attached directly to an ...

Abstract: Twenty-four nitrogen-containing aromatic molecules, mono- and dicyclic homologs from each of 12 different analog sets, were studied to determine their relative acute static toxicities, monitored as population growth impairment to the ciliate Tetrahymena pyriformis. Quantitative structure-activity correlations between the molecular descriptors log l-octanol/water ...

Abstract: In the summary/recommendations for the Ecotoxicology Session of TestSmart--A Humane and Efficient Approach to Screening Information Data Sets (SIDS) Data Workshop, it was recommended that more population growth impairment data using Tetrahymena be generated and compared with available lethality data for the fathead minnow. To comply with this recommendation, ...