68 compounds | Property logER-RBA: Estrogen receptor binding in rat uterine cytosol [%]
| ID | Name | logER-RBA | Details |
|---|---|---|---|
| 1 | Phenol, 4-(phenylmethoxy)- | -3.44 | View |
| 2 | 4-Methylphenol | -4.5 | View |
| 3 | heptyl 4-hydroxybenzoate | -2.09 | View |
| 4 | Benzoic acid, 4-hydroxy-, ethyl ester | -3.22 | View |
| 5 | (6alpha,8alpha,9beta,13alpha,14beta,17alpha)-estra-1,3,5(10)-triene-3,6,17-triol | -0.15 | View |
| 6 | 4-ethylphenol | -4.17 | View |
| 7 | 4,4-bis(4-hydroxyphenyl)pentanoic acid | -3.13 | View |
| 8 | Fulvestrant i | 1.16 | View |
| 9 | (2,4-dihydroxyphenyl)(phenyl)methanone | -2.61 | View |
| 10 | 4-(1,1,3,3-tetramethylbutyl)phenol | -1.82 | View |
| 11 | 1,1a,3,3a,4,5,5,5a,5b,6-Decachlorooctahydro-1,3,4-metheno-2H-cyclobuta[cd]pentalen-2-one | -1.89 | View |
| 12 | 4H-1-Benzopyran-4-one, 3-[[6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy- | -4.09 | View |
| 13 | 4-octylphenol | -2.31 | View |
| 14 | (2E)-3-(4-hydroxyphenyl)-1-phenylprop-2-en-1-one | -2.55 | View |
| 15 | Phenol, 4,4'-(2,2,2-trichloroethylidene)bis- | -0.6 | View |
| 16 | (8alpha,9beta,13alpha,14beta,17alpha)-estra-1,3,5(10)-triene-2,3,17-triol | 1.47 | View |
| 17 | 4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)- | -0.36 | View |
| 18 | 3,9-dihydroxy-6H-[1]benzofuro[3,2-c]chromen-6-one | -0.05 | View |
| 19 | 4H-1-Benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-3,5,7-trihydroxy- | -3.09 | View |
| 20 | 7-hydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one | -1.65 | View |
| 21 | 1,2-Benzenediol, 4,4'-(2,3-dimethyl-1,4-butanediyl)bis- | -1.51 | View |
| 22 | (8alpha,9beta,13alpha,14beta,16beta,17alpha)-estra-1,3,5(10)-triene-3,16,17-triol | 0.99 | View |
| 23 | (8alpha,9beta,13alpha,14beta,17alpha)-estra-1,3,5(10)-triene-3,17-diol | 0.49 | View |
| 24 | (2S)-2-ethylhexyl 4-hydroxybenzoate | -1.74 | View |
| 25 | 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one | -1.61 | View |
| 26 | 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one | -1.55 | View |
| 27 | (5beta,8alpha,9beta,10alpha,17beta)-17-hydroxyandrostan-3-one | -2.89 | View |
| 28 | 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy- | -2.35 | View |
| 29 | Estra-1,3,5(10)-trien-17-one, 3-hydroxy- | 0.86 | View |
| 30 | (8alpha,9beta,13alpha,14beta)-estra-1,3,5(10)-trien-3-ol | 1.14 | View |
| 31 | Phenol, 4,4'-[(1E)-1,2-diethyl-1,2-ethenediyl]bis- | 2.6 | View |
| 32 | 19-Norpregna-1,3,5(10)-trien-20-yne-3,17-diol, (17.alpha.)- | 2.28 | View |
| 33 | [1,1'-Biphenyl]-3-ol | -3.44 | View |
| 34 | Benzene, 1,1',1''-(1-ethenyl-2-ylidene)tris- | -2.78 | View |
| 35 | Phenol, 4-chloro-3-methyl- | -3.38 | View |
| 36 | 4-(1-methyl-1-phenylethyl)phenol | -2.3 | View |
| 37 | 2,5-Cyclohexadien-1-one, 4-[bis(4-hydroxyphenyl)methylene]- | -1.5 | View |
| 38 | 3-ethylphenol | -3.87 | View |
| 39 | Phenol, 4,4'-methylenebis- | -3.02 | View |
| 40 | 4-(2-phenylethyl)phenol | -2.69 | View |
| 41 | Phenol, 4,4'-(1,2-ethenediyl)bis- | -0.55 | View |
| 42 | 2-chloro-4-methylphenol | -3.66 | View |
| 43 | 4-{(1Z)-1-[{4-[2-(dimethylamino)ethoxy]phenyl}(phenyl)methylene]propyl}phenol | 2.24 | View |
| 44 | 19-Norpregn-5(10)-en-20-yn-3-one, 17-hydroxy-, (17.alpha.)- | -0.67 | View |
| 45 | (8alpha,9beta,13alpha,14beta,17alpha)-17-ethynyl-3-methoxyestra-1,3,5(10)-trien-17-ol | 0.35 | View |
| 46 | 3,3-bis(4-hydroxyphenyl)-2-benzofuran-1(3H)-one | -1.87 | View |
| 47 | Benzene, 1-chloro-2-[2,2,2-trichloro-1-(4-chlorophenyl)ethyl]- | -2.85 | View |
| 48 | Phenol, 4,4'-(1-methylethylidene)bis- | -2.11 | View |
| 49 | Benzoic acid, 4-hydroxy-, butyl ester i | -3.07 | View |
| 50 | 4-(1,1-dimethylpropyl)phenol | -3.26 | View |
| 51 | Phenol, 4,4'-(1,2-diethylidene-1,2-ethanediyl)bis- | 1.57 | View |
| 52 | 2-sec-butylphenol | -3.54 | View |
| 53 | 3-chlorobiphenyl-4-ol | -2.77 | View |
| 54 | [1,1'-Biphenyl]-4-ol | -3.04 | View |
| 55 | propyl 4-hydroxybenzoate | -3.22 | View |
| 56 | Benzoic acid, 4-hydroxy-, phenylmethyl ester | -2.54 | View |
| 57 | Phenol, 4,4'-sulfonylbis- i | -3.07 | View |
| 58 | 2-Propen-1-one, 1,3-diphenyl- | -2.82 | View |
| 59 | Phenol, 2,2'-methylenebis[4-chloro- | -2.45 | View |
| 60 | 4-(1,1-dimethylethyl)phenol | -3.61 | View |
| 61 | sec-butylbenzene i | -3.37 | View |
| 62 | methyl 4-hydroxybenzoate | -3.44 | View |
| 63 | 4-dodecylphenol | -1.73 | View |
| 64 | Phenol, 4-(heptyloxy)- | -2.88 | View |
| 65 | Phenol, 4,4'-(1,1-dioxido-3H-2,1-benzoxathiol-3-ylidene)bis- | -3.25 | View |
| 66 | Phenol, 4-chloro-2-methyl- | -3.67 | View |
| 67 | Estra-1,3,5(10)-trien-17-ol, (17.beta.)- | -0.3 | View |
| 68 | (2E)-1-(4-hydroxyphenyl)-3-phenylprop-2-en-1-one | -2.43 | View |
Fang, H.; Tong, W.; Shi, L. M.; Blair, R.; Perkins, R.; Branham, W.; Hass, B. S.; Xie, Q.; Dial, S. L.; Moland, C. L.; al, e. Structure−Activity Relationships for a Large Diverse Set of Natural, Synthetic, and Environmental Estrogens. Chemical Research in Toxicology 2001, 14, 280–294. http://dx.doi.org/10.1021/tx000208y
Blair, R. M. The Estrogen Receptor Relative Binding Affinities of 188 Natural and Xenochemicals: Structural Diversity of Ligands. Toxicological Sciences 2000, 54, 138–153. http://dx.doi.org/10.1093/toxsci/54.1.138
Branham, W. S.; Dial, S. L.; Moland, C. L.; Hass, B. S.; Blair, R. M.; Fang, H.; Shi, L.; Tong, W.; Perkins, R. G.; Sheehan, D. M. Phytoestrogens and Mycoestrogens Bind to the Rat Uterine Estrogen Receptor. The Journal of Nutrition 2002, 132, 658–664. http://dx.doi.org/10.1093/jn/132.4.658
Distributed Structure-Searchable Toxicity (DSSTox) Public Database Network. http://www.epa.gov/NCCT/dsstox/sdf_nctrer.html.