Regression
Karpavičienė, I.; Valiulienė, G.; Raškevičius, V.; Lebedytė, I.; Brukštus, A.; Kairys, V.; Navakauskienė, R.; Čikotienė, I. Synthesis and antiproliferative activity of α-branched α,β-unsaturated ketones in human hematological and solid cancer cell lines. Eur. J. Med. Chem. 2015, 98, 30–48.
Published: Vytautas Raškevičius (2016-03-01)
Abstract: A series of a-branched a,b-unsaturated ketones were prepared via boron trifluoride etherate mediated
reaction between arylalkynes and carboxaldehydes. The evaluation of the antiproliferative activity over
hematological (NB4) and solid cancer (A549, MCF-7) cell lines provided a structure-activity relationship.
5-Parameter QSAR equations were built which were ...