Abstract: The toxicity data of 256 chemicals tested in both the 96-h Pimephales promelas mortality assay and the 2-d Tetrahymena pyriformis growth inhibition assay were evaluated using quantitative structure-activity relationships (QSARs). Each chemical was a priori assigned a mode of action of either narcoses or soft electrophilicity. Narcoses were separated into ...

Abstract: Toxicity data for 200 substituted benzenes tested in the two-day Tetrahymena pyriformis population growth impairment assay representing the neutral narcosis, polar narcosis, respiratory uncoupling, and weak and strong electrophilic mechanisms of toxic action were evaluated. A quantitative structure-toxicity model correlating toxic potency [log(IGC(50)(-)(1))] ...