REPOSITORY QDB RESOURCES CITING NEWS CONTACTS

Bearden, A.P.; Schultz, T.W. Comparison of Tetrahymena and Pimephales Toxicity Based on Mechanism of Action. SAR QSAR Environ. Res. 1998, 9, 3-4, 127–153.

QsarDB Repository

Bearden, A.P.; Schultz, T.W. Comparison of Tetrahymena and Pimephales Toxicity Based on Mechanism of Action. SAR QSAR Environ. Res. 1998, 9, 3-4, 127–153.

QDB archive DOI: 10.15152/QDB.73   DOWNLOAD

QsarDB content

Property pLC50: 96-h Fathead minnow toxicity as log(1/LC50) [log(L/mmol)]

Compounds: 262 | Models: 0 | Predictions: 0

Property pIGC50: 2-day Tetrahymena toxicity as log(1/IGC50) [log(L/mmol)]

Compounds: 262 | Models: 5 | Predictions: 5

12: Nonpolar narcosis

Regression model (regression)

Open in:QDB Explorer QDB Predictor

Name Type n

R2

σ

Training training 70 0.951 0.271
14: Amine narcosis

Regression model (regression)

Open in:QDB Explorer QDB Predictor

Name Type n

R2

σ

Training training 12 0.931 0.286
16: Monoester narcosis

Regression model (regression)

Open in:QDB Explorer QDB Predictor

Name Type n

R2

σ

Training training 8 0.854 0.302
18: Diester narcosis

Regression model (regression)

Open in:QDB Explorer QDB Predictor

Name Type n

R2

σ

Training training 11 0.875 0.278
20: Polar narcosis

Regression model (regression)

Open in:QDB Explorer QDB Predictor

Name Type n

R2

σ

Training training 50 0.856 0.319

Property MOA: Mode of action

Compounds: 262 | Models: 0 | Predictions: 0

Citing

When using this QDB archive, please cite (see details) it together with the original article:

Metadata

Show simple item record

dc.date.accessioned 2012-05-23T16:06:59Z
dc.date.available 2012-05-23T16:06:59Z
dc.date.issued 2012-05-23
dc.identifier.uri http://hdl.handle.net/10967/73
dc.identifier.uri http://dx.doi.org/10.15152/QDB.73
dc.description.abstract The toxicity data of 256 chemicals tested in both the 96-h Pimephales promelas mortality assay and the 2-d Tetrahymena pyriformis growth inhibition assay were evaluated using quantitative structure-activity relationships (QSARs). Each chemical was a priori assigned a mode of action of either narcoses or soft electrophilicity. Narcoses were separated into nonpolar narcosis, polar narcosis, monoester narcosis, diester narcosis, amine narcosis, and weak acid respiratory uncoupling based on the presence or absence of specific toxicophores. Toxicity of each narcotic mechanism was initially regressed against the 1-octanol-water partition coefficient (log K(ow)). The slopes of these log K(ow) based QSARs were observed to ascertain whether a relationship exists between the value of the slope and the reactivity of the mechanism of action. With both the fish and ciliate data nonpolar narcosis was the least reactive mechanism. It was followed by the other reversible narcoses. The soft electrophile mode was separated into the specific molecular mechanisms of: SN2 reactors, Schiff-base formers, Michael-type addition, or proelectrophilicity (precursors to Michael-type addition chemicals). These mechanisms were represented structurally by the nitrobenzenes, aldehydes, polarized alpha-beta unsaturates (e.g., acrylates and methacrylates), and acetylenic alcohols, respectively. Electrophilic toxicity was not correlated with hydrophobicity. QSARs based on molecular orbital (MO) quantum chemical descriptors were used to improve the predictability of the electrophilic mechanisms. Relevant descriptors include average superdelocalizability (Svna) for the nucleophilic addition of the nitrobenzene; atom x and y acceptor superdelocalizability (Ax); and bond order (Bx y) for the Michael-type addition of the acrylates; and log K(ow) and atom x net charge (Qx) for the Schiff-base forming aldehydes. The pertinent descriptors for proelectrophiles were log K(ow) and Svna. Principal differences between the QSARs for the two biological endpoints were observed for the ester narcoses, proelectrophiles, and Schiff-base forming aldehydes.
dc.publisher Villu Ruusmann
dc.title Bearden, A.P.; Schultz, T.W. Comparison of Tetrahymena and Pimephales Toxicity Based on Mechanism of Action. SAR QSAR Environ. Res. 1998, 9, 3-4, 127–153.
qdb.property.endpoint 3. Ecotoxic effects 3.3. Acute toxicity to fish
qdb.property.endpoint 6. Other (Acute toxicity to ciliate protozoa)
qdb.property.species Pimephales promelas (Fathead minnow)
qdb.property.species Tetrahymena pyriformis
qdb.descriptor.application MedChem 3.55
bibtex.entry article
bibtex.entry.author Bearden, A. P.
bibtex.entry.author Schultz, T. W.
bibtex.entry.doi 10.1080/10629369808039153
bibtex.entry.journal SAR QSAR Environ. Res.
bibtex.entry.number 3-4
bibtex.entry.pages 127–153
bibtex.entry.title Comparison of Tetrahymena and Pimephales Toxicity Based on Mechanism of Action
bibtex.entry.volume 9
bibtex.entry.year 1998
qdb.model.type Regression model (regression)


Files in this item

Name Description Format Size View
757987366.qdb.zip n/a application/x-zip 15.48Kb View/Open

This item appears in the following Collection(s)

Show simple item record