University of Tartu, Institute of Chemistry, Molecular Technology (Estonia)
Browsing University of Tartu, Institute of Chemistry, Molecular Technology (Estonia) by Endpoint

Browsing University of Tartu, Institute of Chemistry, Molecular Technology (Estonia) by Endpoint "5. Toxicokinetics 5.4. Blood-brain barrier penetration"

QsarDB Repository

Browsing University of Tartu, Institute of Chemistry, Molecular Technology (Estonia) by Endpoint "5. Toxicokinetics 5.4. Blood-brain barrier penetration"

Showing items 1-2 of 2

Abraham, M. H.; Ibrahim, A.; Zhao, Y.; Acree, W. E. A data base for partition of volatile organic compounds and drugs from blood/plasma/serum to brain, and an LFER analysis of the data. J. Pharm. Sci. 2006, 95, 10, 2091–2100.

Published: Iiris Kahn (2015-01-14)

Abstract: Literature values of the in vivo distribution (BB) of drugs from blood, plasma, or serum to rat brain have been assembled for 207 compounds (233 data points). Wefind that data on in vivo distribution from blood, plasma, and serum to rat brain can all be combined. Application of our general linear free energy relationship (LFER) to the 207 compounds yields an ...

Toxicokinetics Regression
Clark, D. E. Rapid calculation of polar molecular surface area and its application to the prediction of transport phenomena. 2. Prediction of blood–brain barrier penetration. J. Pharm. Sci. 1999, 88, 815–821.

Published: Geven Piir, Sulev Sild (2017-05-18)

Abstract: This paper describes the derivation of a simple QSAR model for the prediction of log BB from a set of 55 diverse organic compounds. The model contains two variables: polar surface area (PSA) and calculated logP, both of which can be rapidly computed. It therefore permits the prediction of log BB for large compound sets, such as virtual combinatorial libraries. ...

Toxicokinetics Regression

Showing items 1-2 of 2

Search

Chemical search

Advanced Search

Browse

All of QsarDB
Communities & Collections By Submit Date Authors Titles Journals Endpoints Species Descriptor calculation software Modeling software Model type
This Community
By Submit Date Authors Titles Journals Endpoints Species Descriptor calculation software Modeling software Model type

My Account