Browsing University of Tartu, Institute of Chemistry, Molecular Technology (Estonia) by Endpoint "3. Ecotoxic effects 3.3. Acute toxicity to fish"

Showing items 1-9 of 9

Bearden, A.P.; Schultz, T.W. Comparison of Tetrahymena and Pimephales Toxicity Based on Mechanism of Action. SAR QSAR Environ. Res. 1998, 9, 3-4, 127–153.

Published: Villu Ruusmann (2012-05-23)

Abstract: The toxicity data of 256 chemicals tested in both the 96-h Pimephales promelas mortality assay and the 2-d Tetrahymena pyriformis growth inhibition assay were evaluated using quantitative structure-activity relationships (QSARs). Each chemical was a priori assigned a mode of action of either narcoses or soft electrophilicity. Narcoses were separated into ...

EcoTox Regression
Bearden, A.P.; Schultz, T.W. Structure-Activity Relationships for Pimephales and Tetrahymena: a Mechanism of Action Approach. Environ. Toxicol. Chem. 1997, 16, 6, 1311–1317.

Published: Villu Ruusmann (2012-05-23)

Abstract: The toxicity data of 74 chemicals tested in both the 96-h fathead minnow (Pimephales promelas) mortality assay and the 2-d Tetrahymena pyriformis (a protozoan) growth inhibition assay were evaluated using quantitative structure-activity relationships (QSARs). Each chemical was a priori assigned a mechanism of acute toxic action from either nonpolar narcosis, ...

EcoTox Regression
Furuhama, A.; Hasunuma, K.; Aoki, Y. Interspecies quantitative structure–activity–activity relationships (QSAARs) for prediction of acute aquatic toxicity of aromatic amines and phenols. SAR QSAR Environ. Res. 2015, 26, 301–323.

Published: Geven Piir, Sulev Sild (2017-05-08)

Abstract: We propose interspecies quantitative structure–activity–activity relationships (QSAARs), that is, QSARs with descriptors, to estimate species-specific acute aquatic toxicity. Using training datasets consisting of more than 100 aromatic amines and phenols, we found that the descriptors that predicted acute toxicities to fish (Oryzias latipes) and algae were ...

EcoTox Regression
Jaworska, J.S.; Hunter, R.S.; Schultz, T.W. Quantitative Structure-Toxicity Relationships and Volume Fraction Analyses for Selected Esters. Arch. Environ. Contam. Toxicol. 1995, 29, 1, 86–93.

Published: Villu Ruusmann (2012-05-23)

Abstract: The acute toxicity of aliphatic and aromatic mono and diesters in two eucaryotic organisms was compared. The test systems were the static 2-d Tetrahymena pyriformis 50% population growth impairment (IGC50(-1)) assay, and the flow-through 4-d Pimephales promelas 50% mortality (LC50(-1)) assay. In ciliates, esters act via the nonpolar narcosis mechanism of toxic ...

EcoTox Regression
Könemann, H. Quantitative structure-activity relationships in fish toxicity studies Part 1: Relationship for 50 industrial pollutants. Toxicology 1981, 19, 3, 209–221.

Published: Uko Maran (2013-09-13)

Abstract: LC50-experiments have been conducted using guppies subjected to 72 industrial pollutants. The correlation of the LC50 with several expressions of the hydrophobicity of these chemicals has been studied. Calculated logP(oct) values appeared to satisfy more than HPLC retention indices, solubility data or molecular connectivity indices. One QSAR, with logP(oct) ...

EcoTox Regression DescriptorCalculation
Ren, S.; Frymier, P.D.; Schultz, T.W. An exploratory study of the use of multivariate techniques to determine mechanisms of toxic action. Ecotoxicol. Environ. Saf. 2003, 55, 1, 86–97.

Published: Villu Ruusmann (2012-05-23)

Abstract: The most successful quantitative structure-activity relationships have been developed by separating compounds by their mechanisms of toxic action (MOAs). However, to correctly determine the MOA of a compound is often not easy. We investigated the usefulness of discriminant analysis and logistic regression in determining MOAs. The discriminating variables used ...

EcoTox Dataset
Schultz, T.W. TETRATOX: Tetrahymena pyriformis population growth impairment endpoint - a surrogate for fish lethality. Toxicol. Methods 1997, 7, 4, 289–309.

Published: Villu Ruusmann (2012-05-23)

Abstract: A short-term, static protocol using the common freshwater ciliate Tetrahymena pyriformis (strain GL-C) is reported. The 50% impairment growth concentration (IGC 50) is the endpoint of choice. Cultures are reared in 50 mL of a semi defined medium in 250-mL Erlenmeyer flasks. Definitive test replicates consist of a minimum of 5 different concentrations of each ...

EcoTox Dataset
Seward, J.R.; Hamblen, E.L.; Schultz, T.W. Regression comparisons of Tetrahymena pyriformis and Poecilia reticulata toxicity. Chemosphere 2002, 47, 1, 93–101.

Published: Villu Ruusmann (2012-05-23)

Abstract: The toxicity data of chemicals common to both the Poecilia reticulata mortality assay and the Tetrahymena pyriformis growth impairment assay were evaluated. Two chemicals were not toxic at saturation in the T. pyriformis assay. In addition, due to abiotic transformation, a third chemical was removed from further consideration. Each chemical was a priori assigned ...

EcoTox Dataset
Sinks, G.D.; Schultz, T.W. Correlation of Tetrahymena and Pimephales Toxicity: Evaluation of 100 Additional Compounds. Environ. Toxicol. Chem. 2001, 20, 4, 917–921.

Published: Villu Ruusmann (2012-05-23)

Abstract: In the summary/recommendations for the Ecotoxicology Session of TestSmart--A Humane and Efficient Approach to Screening Information Data Sets (SIDS) Data Workshop, it was recommended that more population growth impairment data using Tetrahymena be generated and compared with available lethality data for the fathead minnow. To comply with this recommendation, ...

EcoTox Dataset

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