Kidron, H.; Vellonen, K.-S.; del Amo, E. M.; Tissari, A.; Urtti, A. Prediction of the Corneal Permeability of Drug-Like Compounds. Pharm. Res. 2010, 27, 1398–1407.
Compound
| ID: | 50 | |
|---|---|---|
| Name: | Trichlormethazolamide | |
| Description: | ||
| Labels: | ||
| CAS: | ||
| InChi Code: | InChI=1S/C5H5Cl3N4O3S2/c1-12-3(10-2(13)5(6,7)8)16-4(11-12)17(9,14)15/h1H3,(H2,9,14,15)/b10-3+ |
Properties
perm: Corneal permeability [cm/s]
| Value | Source or prediction |
|---|---|
| 1.1E-5 |
experimental value |
logPapp: The logarithm of the corneal permeability [log(cm/s)]
| Value | Source or prediction |
|---|---|
| -4.96 |
experimental value |
| -5.05 |
Eq.3b: Model for drug-like compounds at pH 7.4 (Trainig set) |
| -5.17 |
Eq.4b: Model for drug-like compounds at pH 8.0 (Trainig set) |