Abstract: Abstract Vertebrate testing under the European Union's regulation on Registration, Evaluation, Authorisation and Restriction of Chemical substances (REACH) is discouraged, and the use of alternative nontesting approaches such as quantitative structure?activity relationships (QSARs) is encouraged. However, robust QSARs predicting chronic ecotoxicity of organic ...

Abstract: Twenty-four nitrogen-containing aromatic molecules, mono- and dicyclic homologs from each of 12 different analog sets, were studied to determine their relative acute static toxicities, monitored as population growth impairment to the ciliate Tetrahymena pyriformis. Quantitative structure-activity correlations between the molecular descriptors log l-octanol/water ...