Schultz, T.W.; Holcombe, G.W.; Phipps, G.L. Relationships of quantitative structure-activity to comparative toxicity of selected phenols in the Pimephales promelas and Tetrahymena pyriformis test systems. Ecotoxicol. Environ. Saf. 1986, 12, 2, 146–153.

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Schultz, T.W.; Holcombe, G.W.; Phipps, G.L. Relationships of quantitative structure-activity to comparative toxicity of selected phenols in the Pimephales promelas and Tetrahymena pyriformis test systems. Ecotoxicol. Environ. Saf. 1986, 12, 2, 146–153.

QDB archive DOI: 10.15152/QDB.24   DOWNLOAD

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Property pIGC50: 48- to 60-h Tetrahymena toxicity as log(1/IGC50) [log(L/mmol)]

4: All compounds

Regression model (regression)

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  • Ruusmann, V. Data for: Relationships of quantitative structure-activity to comparative toxicity of selected phenols in the Pimephales promelas and Tetrahymena pyriformis test systems. QsarDB repository, QDB.24. 2012. http://dx.doi.org/10.15152/QDB.24

  • Schultz, T. W.; Holcombe, G. W.; Phipps, G. L. Relationships of quantitative structure-activity to comparative toxicity of selected phenols in the Pimephales promelas and Tetrahymena pyriformis test systems. Ecotoxicol. Environ. Saf. 1986, 12, 146–153. http://dx.doi.org/10.1016/0147-6513(86)90051-5

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dc.date.accessioned2012-05-23T15:39:34Z
dc.date.available2012-05-23T15:39:34Z
dc.date.issued2012-05-23
dc.identifier.urihttp://hdl.handle.net/10967/24
dc.identifier.urihttp://dx.doi.org/10.15152/QDB.24
dc.description.abstractThe relative toxic response of 27 selected phenols in the 96-hr acute flowthrough Pimephales promelas (fathead minnow) and the 48- to 60-hr chronic static Tetrahymena pyriformis (ciliate protozoan) test systems was evaluated. Log Kow-dependent linear regression analyses revealed that the data from each test system consisted of two linear equations. The less toxic chemicals form a relationship which models polar narcosis; these chemicals are slightly more active than the baseline toxicity of nonionic narcotic chemicals. The more toxic chemicals form a relationship which models uncoupling of oxidative phosphorylation. Regression analysis of fathead minnow toxicity (log LC50 (mol/liter] vs Tetrahymena toxicity (log BR (mmol/liter] showed good correlation between the two systems. An exception appears to be 4-nitrophenol, which is more active in the Tetrahymena system than in the fathead minnow and lies outside the 95% confidence interval. Reanalysis following deletion of 4-nitrophenol results in the equation log LC50 = -0.9192 (log BR) -3.5035; n = 26, r2 = 0.887.
dc.publisherVillu Ruusmann
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleSchultz, T.W.; Holcombe, G.W.; Phipps, G.L. Relationships of quantitative structure-activity to comparative toxicity of selected phenols in the Pimephales promelas and Tetrahymena pyriformis test systems. Ecotoxicol. Environ. Saf. 1986, 12, 2, 146–153.
qdb.property.endpoint6. Other (Acute toxicity to ciliate protozoa)
qdb.property.speciesTetrahymena pyriformis
bibtex.entryarticle
bibtex.entry.authorSchultz, T. W.
bibtex.entry.authorHolcombe, G. W.
bibtex.entry.authorPhipps, G. L.
bibtex.entry.doi10.1016/0147-6513(86)90051-5
bibtex.entry.journalEcotoxicol. Environ. Saf.
bibtex.entry.number2
bibtex.entry.pages146–153
bibtex.entry.titleRelationships of quantitative structure-activity to comparative toxicity of selected phenols in the Pimephales promelas and Tetrahymena pyriformis test systems
bibtex.entry.volume12
bibtex.entry.year1986
qdb.model.typeRegression model (regression)


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