Abstract: Draize rabbit eye test scores, as modified maximum average score (MMAS), for 68 pure bulk liquids were adjusted by the liquid-saturated vapor pressure P°. These 68 adjusted scores, as log (MMAS/P°), were shown to be completely equivalent to eye irritation thresholds (EIT), expressed as log (1/EIT), for 23 compounds in humans. Thus, for the first time the Draize ...

Abstract: To develop a computational model for optimisation of low corneal permeability, which is a key feature in ocular drug development. We have used multivariate analysis to build corneal permeability models based on a structurally diverse set of 58 drug-like compounds. According to the models, the most important parameters for permeability are logD at physiologically ...