Schultz, T.W.; Ralston, K.E.; Roberts, D.W.; Veith, G.D.; Aptula, A.O. Structure-activity relationships for abiotic thiol reactivity and aquatic toxicity of halo-substituted carbonyl compounds. SAR QSAR Environ. Res. 2007, 18, 1-2, 21–29.

27 compounds | Property IGC50: 40-h Tetrahymena toxicity as IGC50 [mmol/L]

ID	Name	IGC50	Details
1	Ethyl iodoacetate	0.0012	View
2	Ethyl acetate	NTAS	View
3	2-Bromoacetophenone	0.0015	View
4	Acetophenone	NTAS	View
5	(2-Bromoethyl)benzene	NTAS	View
6	2-Chloroacetamide	0.92	View
7	Propionamide	NTAS	View
8	Ethyl bromoacetate	0.0021	View
9	Ethyl chloroacetate	0.088	View
10	Ethyl fluoroacetate	NTAS	View
11	Propyl bromoacetate	0.0049	View
12	Propyl chloroacetate	0.066	View
13	2-Bromoacetamide	0.03	View
14	Methyl bromoacetate	0.011	View
15	Methyl 3-bromopropionate	0.094	View
16	Methyl 4-bromobutyrate	0.855	View
17	Methyl 5-bromovalerate	NTAS	View
18	Methyl 2-bromopropionate	0.066	View
19	Methyl 2-bromobutyrate	0.095	View
20	Methyl 2-bromooctanoate	NTAS	View
21	2-(2-Bromoacetyl)naphthalene	0.0011	View
22	1-(Bromoacetyl)pyrene	0.0041	View
23	3-(Bromoacetyl)coumarin	0.0022	View
24	2-(2-Bromoacetyl)thiophene	0.006	View
25	tert-Butyl bromoacetate	0.0039	View
26	Methyl chloroacetate	0.131	View
27	tert-Butyl chloroacetate	0.136	View

Bibliography

Schultz, T. W.; Ralston, K. E.; Roberts, D. W.; Veith, G. D.; Aptula, A. O. Structure-activity relationships for abiotic thiol reactivity and aquatic toxicity of halo-substituted carbonyl compounds. SAR QSAR Environ. Res. 2007, 18, 21–29. http://dx.doi.org/10.1080/10629360601033424
Schultz, T. W. TETRATOX: Tetrahymena pyriformis population growth impairment endpoint - a surrogate for fish lethality. Toxicol. Mech. Meth. 1997, 7, 289–309. http://dx.doi.org/10.1080/105172397243079