Seward, J.R.; Cronin, M.T.D.; Schultz, T.W. Structure-Toxicity Analyses of Tetrahymena Pyriformis Exposed to Pyridines - An Examination Into Extension of Surface-Response Domains. SAR QSAR Environ. Res. 2001, 11, 5, 489–512.

112 compounds | Property pIGC50: 40-h Tetrahymena toxicity as log(1/IGC50) [log(L/mmol)]

ID	Name	pIGC50	Details
1	2-Hydroxy-6-methylpyridine	-1.35	View
2	2,4-Dihydroxypyridine	-1.46	View
3	2-Ethylpyridine	-0.87	View
4	5-Chloro-2-pyridinol	-0.75	View
5	3-Cyano-4,6-dimethyl-2-hydroxypyridine	-0.70	View
6	5-Hydroxy-2-methylpyridine	-0.88	View
7	6-Chloro-2-picoline	-0.48	View
8	3-Methylpyridine	-0.99	View
9	2,4-Lutidine	-0.65	View
10	2-Chloropyridine	-0.84	View
11	2-Methylpyridine	-1.01	View
12	2-Fluoropyridine	-1.20	View
13	2-(Dimethylaminomethyl)-3-hydroxypyridine	-1.26	View
14	4-ChloropyridineHCl	-0.86	View
15	3-Chloropyridine	-0.81	View
16	5-Ethyl-2-methylpyridine	-0.18	View
17	4-Methylpyridine	-0.88	View
18	2-Dimethylaminopyridine	-0.55	View
19	Pyridine	-1.27	View
20	4-Ethylpyridine	-0.46	View
21	3,4-Lutidine	-0.50	View
22	2-Phenylpyridine	0.27	View
23	3-Bromopyridine	-0.49	View
24	2-Hydroxy-4-methyl-3-nitropyridine	-0.68	View
25	2,3,5,6-Tetrachloro-4-pyridinethiol	1.37	View
26	4-(tert)Butylpyridine	0.20	View
27	2-Benzylpyridine	0.38	View
28	4-Dimethylaminopyridine	-0.63	View
29	2-Bromopyridine	-0.54	View
30	4-Benzoylpyridine	-0.09	View
31	2-Pyridinemethanol	-1.51	View
32	3,5-Dibromopyridine	0.32	View
33	3-Pyridinemethanol	-1.51	View
34	Methylisonicotinate	-0.81	View
35	3,5-Diacetyl-2,6-dimethylpyridine	-0.54	View
36	4-BromopyridineHCl	-0.31	View
37	3-Phenylpyridine	0.47	View
38	4-Pyridinemethanol	-1.33	View
39	4-Bromophenyl-3-pyridyl-ketone	0.82	View
40	2,6-Dibromopyridine	0.25	View
41	3-Benzylpyridine	0.68	View
42	2-Benzylamino-4-methylpyridine	0.95	View
43	2,3-Dihydroxypyridine	-0.34	View
44	4-Benzylpyridine	0.65	View
45	4-Phenylpyridine	0.66	View
46	4-Acetylpyridine	-0.87	View
47	1,2-Bis(4-pyridyl)ethane	-0.03	View
48	5-Chloro-3-pyridinol	0.10	View
49	2-Amino-4,6-dimethylpyridine	-0.22	View
50	2-Hydroxypyridine	-1.61	View
51	2-Cyanopyridine	-0.83	View
52	2-Hydroxy-4-methyl-5-nitropyridine	-0.17	View
53	4-Cyanopyridine	-0.82	View
54	2-Methoxy-5-nitropyridine	-0.01	View
55	2-Amino-3-picoline	-0.57	View
56	4-Pyridinealdoxime	-0.55	View
57	2-Bromo-3-pyridinol	0.00	View
58	2-Chloro-3-pyridinol	-0.04	View
59	Diethyl-3,4-pyridine-dicarboxylate	-0.13	View
60	3-Cyanopyridine	-0.75	View
61	3-Hydroxypyridine	-0.66	View
62	4-Amino-3,5-dichloro-2,6-difluoropyridine	0.60	View
63	6-Chloro-2-pyridinol	-0.29	View
64	2-Aminopyridine	-0.61	View
65	4-Carboxylpyridine	-1.38	View
66	Pentachloropyridine	1.68	View
67	2-Amino-5-chloropyridine	-0.03	View
68	3-Carboxylpyridine	-1.36	View
69	2-Chloro-4-methyl-5-nitropyridine	0.41	View
70	Isonicotinamide	-1.02	View
71	2-(Benzylthio)-3-nitropyridine	1.72	View
72	2-Amino-3,5-dibromopyridine	0.85	View
73	2-Chloro-4-methyl-3-nitropyridine	0.29	View
74	2-Vinylpyridine	0.24	View
75	4-Aminopyridine	-0.44	View
76	2-Amino-3-hydroxypyridine	0.05	View
77	3-Hydroxy-6-methyl-2-nitropyridine	0.39	View
78	5-Amino-2-chloropyridine	0.17	View
79	2-Amino-3-nitropyridine	-0.01	View
80	4-Hydroxypyridine	-1.59	View
81	2,6-Diaminopyridine	-0.59	View
82	3-Pyridinecarboxaldehyde	-0.15	View
83	3-Aminopyridine	-0.48	View
84	4-Pyridinecarboxaldehyde	-0.21	View
85	2-Amino-5-bromopyridine	0.49	View
86	2-Carboxylpyridine	0.07	View
87	2-Amino-4-methyl-3-nitropyridine	0.50	View
88	Pentafluoropyridine	0.70	View
89	2-Amino-5-nitropyridine	0.22	View
90	2-Amino-4-methyl-5-nitropyridine	0.37	View
91	2,3-Diaminopyridine	-0.11	View
92	2-Amino-3,5-dichloropyridine	1.46	View
93	4-Vinylpyridine	1.07	View
94	2-Chloro-3-nitropyridine	0.87	View
95	2-Bromo-5-nitropyridine	1.07	View
96	4-Nitropyridine	0.41	View
97	3-Hydroxy-2-nitropyridine	0.87	View
98	2,6-Dichloro-3-nitropyridine	2.03	View
99	2-Chloro-3,5-dinitropyridine	2.64	View
100	2,6-Diphenylpyridine	NTAS	View
101	2-Amino-5-bromo-3-nitropyridine	NTAS	View
102	2,6-Dihydroxy-4-methyl-3-pyridinecarbonitrile	NTAS	View
103	Ethyl-2-pyridylacetate	-0.92	View
104	3-(3-Pyridyl)-1-propanol	-0.84	View
105	2-(2-Aminoethyl)pyridine	-0.74	View
106	3-Amino-2-chloropyridine	-0.71	View
107	2-Pyridinecarboxaldehyde	-0.14	View
108	4,4'-Dipyridyl	0.21	View
109	2,3,5-Trichloropyridine	0.34	View
110	5-Chloro-2,3-pyridinediol	0.57	View
111	2-Chloro-5-nitropyridine	0.80	View
112	2-Chloro-6-methoxy-3-nitropyridine	1.36	View

Bibliography

Seward, J. R.; Cronin, M. T. D.; Schultz, T. W. Structure-Toxicity Analyses of Tetrahymena Pyriformis Exposed to Pyridines - An Examination Into Extension of Surface-Response Domains. SAR QSAR Environ. Res. 2001, 11, 489–512. http://dx.doi.org/10.1080/10629360108035365
Schultz, T. W.; Moulton, B. A. Structure-activity relationships for nitrogen-containing aromatic molecules. Environ. Toxicol. Chem. 1985, 4, 353–359. http://dx.doi.org/10.1002/etc.5620040310
Schultz, T. W.; Applehans, F. M. Correlations for the acute toxicity of multiple nitrogen substituted aromatic molecules. Ecotox. Environ. Safe. 1985, 10, 75–85. http://dx.doi.org/10.1016/0147-6513(85)90009-0
Schultz, T. W.; Dawson, D. A.; Lin, D. T. Comparative toxicity of selected nitrogen-containing aromatic compounds in the Tetrahymena pyriformis and Pimephales promelas test systems. Chemosphere 1989, 18, 2283–2291.
Schultz, T. W. TETRATOX: Tetrahymena pyriformis population growth impairment endpoint - a surrogate for fish lethality. Toxicol. Mech. Meth. 1997, 7, 289–309. http://dx.doi.org/10.1080/105172397243079

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Seward, J.R.; Cronin, M.T.D.; Schultz, T.W. Structure-Toxicity Analyses of Tetrahymena Pyriformis Exposed to Pyridines - An Examination Into Extension of Surface-Response Domains. SAR QSAR Environ. Res. 2001, 11, 5, 489–512.

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