Seward, J.R.; Cronin, M.T.D.; Schultz, T.W. The effect of precision of molecular orbital descriptors on toxicity modeling of selected pyridines. SAR QSAR Environ. Res. 2002, 13, 2, 325–340.

38 compounds | Property pIGC50: 40-h Tetrahymena toxicity as log(1/IGC50) [log(L/mmol)]

ID	Name	pIGC50	Details
1	1,2-Bis (4-pyridyl)ethane	-0.03	View
2	2,3,5,6-Tetrachloro-4-pyridinethiol	1.37	View
3	2,4-Dihydroxypyridine	-1.46	View
4	2,6-Diaminopyridine	-0.59	View
5	2,6-Dichloro-3-nitropyridine	2.03	View
6	2,6-Dihydroxy-4-methyl-3-pyridine carbonitrile	NTAS	View
7	2,6-Diphenylpyridine	NTAS	View
8	2,6-Pyridinecarboxylic acid	0.12	View
9	2-Amino-3-hydroxypyridine	0.05	View
10	2-Amino-3-nitropyridine	-0.01	View
11	2-Amino-3-picoline	-0.57	View
12	2-Amino-5-chloropyridine	-0.03	View
13	2-Chloro-3,5-dinitropyridine	2.64	View
14	2-Chloro-5-nitropyridine	0.80	View
15	2-Chloro-6-methoxy-3-nitropyridine	1.36	View
16	2-Cyanopyridine	-0.83	View
17	2-Hydroxy-6-methylpyridine	-1.35	View
18	2-Methoxy-5-nitropyridine	-0.01	View
19	3,5-Dibromopyridine	0.32	View
20	3-Bromopyridine	-0.49	View
21	3-Chloropyridine	-0.81	View
22	3-Cyano-4,6-dimethyl-2-hydroxylpyridine	-0.70	View
23	3-Hydroxy-6-methyl-2-nitropyridine	0.39	View
24	3-Phenylpyridine	0.47	View
25	4,4'-Dipyridyl	0.21	View
26	4-Acetylpyridine	-0.87	View
27	4-Aminopyridine	-0.44	View
28	4-Benzylpyridine	0.65	View
29	4-Bromophenyl-3-pyridylketone	0.82	View
30	4-Ethylpyridine	-0.46	View
31	4-Hydroxypyridine	-1.59	View
32	4-Nitropyridine	0.41	View
33	4-Pyridinealdoxime	-0.55	View
34	5-Chloro-2,3-pyridinediol	0.57	View
35	5-Chloro-2-pyridinol	-0.75	View
36	5-Ethyl-2-methyl pyridine	-0.18	View
37	Pentachloropyridine	1.68	View
38	Pyridine	-1.27	View

Bibliography

Seward, J. R.; Cronin, M. T. D.; Schultz, T. W. The effect of precision of molecular orbital descriptors on toxicity modeling of selected pyridines. SAR QSAR Environ. Res. 2002, 13, 325–340. http://dx.doi.org/10.1080/10629360290002802
Schultz, T. W.; Moulton, B. A. Structure-activity relationships of selected pyridines: I. Substituent constant analysis. Ecotox. Environ. Safe. 1985, 10, 97–111. http://dx.doi.org/10.1016/0147-6513(85)90011-9
Schultz, T. W.; Applehans, F. M. Correlations for the acute toxicity of multiple nitrogen substituted aromatic molecules. Ecotox. Environ. Safe. 1985, 10, 75–85. http://dx.doi.org/10.1016/0147-6513(85)90009-0
Schultz, T. W.; Dawson, D. A.; Lin, D. T. Comparative toxicity of selected nitrogen-containing aromatic compounds in the Tetrahymena pyriformis and Pimephales promelas test systems. Chemosphere 1989, 18, 2283–2291.
Schultz, T. W. TETRATOX: Tetrahymena pyriformis population growth impairment endpoint - a surrogate for fish lethality. Toxicol. Mech. Meth. 1997, 7, 289–309. http://dx.doi.org/10.1080/105172397243079