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10967/191 - QDB Compounds

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Kidron, H.; Vellonen, K.-S.; del Amo, E. M.; Tissari, A.; Urtti, A. Prediction of the Corneal Permeability of Drug-Like Compounds. Pharm. Res. 2010, 27, 1398–1407.

69 compounds | Property perm: Corneal permeability [cm/s]

ID Name perm Ref Details
1 Acetazolamide 9.1E-7 [1,2] View
2 Alprenolol 2.9E-5 [3] View
3 Atenolol 6.7E-7 [4] View
4 Benzolamide 1.4E-7 [1] View
5 Bevantolol 5.4E-5 [4] View
6 N-bromoacetazolamide 3.8E-7 [1] View
7 Bufuralol 5.7E-5 [4] View
8 Chlorzolamide 1.8E-5 [1] View
9 Clonidine 3.1E-5 [3,5] View
10 Corynanthine 1.1E-5 [5] View
11 Cyclophosphamide 1.1E-5 [6] View
12 Ethoxazolamide 5.6E-5 [1] View
13 2-benzothiazolesulfonamide 3.6E-5 [7] View
14 6-hydroxy-2-benzo-thiazolesulfonamide 5.6E-6 [7] View
15 6-chloro-2-benzo-thiazolesulfonamide 4.3E-5 [7] View
16 4,6-dichloro-2-benzo-thiazolesulfonamide 3.9E-5 [7] View
17 6-amino-2-benzo-thiazolesulfonamide 6.7E-6 [7] View
18 6-nitro-2-benzo-thiazolesulfonamide 6.6E-6 [7] View
19 6-hydroxyethoxy-2-benzothiazolesulfonamide 1.5E-6 [7] View
20 6-benzyloxy-2-benzo-thiazolesulfonamide 4.7E-5 [7] View
21 6-acetamido-2-benzo-thiazolesulfonamide 4.7E-6 [7] View
22 Levobunolol 2.0E-5 [3,4] View
23 Labetalol 1.4E-5 [3] View
24 Methazolamide 2.6E-6 [1] View
25 5-imino-4-methyl-1,3,4-thiadiazoline-2-sulfonamide 7.8E-7 [1] View
26 Metoprolol 2.5E-5 [3,4] View
27 Nadolol 1.0E-6 [4] View
28 Oxprenolol 2.9E-5 [3,4] View
29 Penbutolol 4.5E-5 [4] View
30 Phenylephrine 9.4E-7 [5] View
31 Pindolol 1.0E-5 [3] View
32 Propranolol 4.8E-5 [4] View
33 Rauwolfine 9.2E-6 [5] View
34 6H,7H,8H,9H-[1,2,3]thiadiazolo[5,4-h]isoquinoline i 7.9E-5 [5] View
35 Benalfocin i 7.1E-5 [5] View
36 5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline i 4.9E-5 [5] View
37 Sotalol 1.6E-6 [4] View
38 1[(N-methylamino) sulfonyl]-4-chloro-benzene 6.5E-5 [2] View
39 4-chlorobenzene-1-sulfonamide 5.5E-5 [2] View
40 (3Z)-3-(phenylimino)-[1,2,4]thiadiazolo[3,4-b][1,3,4]thiadiazole-6-sulfonamide i 7.9E-6 [8] View
41 (3Z)-3-[(3-chlorophenyl)imino]-[1,2,4]thiadiazolo[3,4-b][1,3,4]thiadiazole-6-sulfonamide i 1.3E-5 [8] View
42 (3Z)-3-[(4-chlorophenyl)imino]-[1,2,4]thiadiazolo[3,4-b][1,3,4]thiadiazole-6-sulfonamide i 8.3E-6 [8] View
43 (3Z)-3-[(3-methoxyphenyl)imino]-[1,2,4]thiadiazolo[3,4-b][1,3,4]thiadiazole-6-sulfonamide i 4.5E-6 [8] View
44 (3Z)-3-[(4-methoxyphenyl)imino]-[1,2,4]thiadiazolo[3,4-b][1,3,4]thiadiazole-6-sulfonamide i 5.2E-6 [8] View
45 (3Z)-3-[(4-hydroxyphenyl)imino]-[1,2,4]thiadiazolo[3,4-b][1,3,4]thiadiazole-6-sulfonamide i 3.5E-7 [8] View
46 (3Z)-3-[(3-fluorophenyl)imino]-[1,2,4]thiadiazolo[3,4-b][1,3,4]thiadiazole-6-sulfonamide i 6.4E-6 [8] View
47 (3Z)-3-[(4-fluorophenyl)imino]-[1,2,4]thiadiazolo[3,4-b][1,3,4]thiadiazole-6-sulfonamide i 4.1E-6 [8] View
48 (3Z)-3-{[4-(dimethylamino)phenyl]imino}-[1,2,4]thiadiazolo[3,4-b][1,3,4]thiadiazole-6-sulfonamide i 5.8E-6 [8] View
49 Timolol 1.2E-5 [3,4] View
50 Trichlormethazolamide 1.1E-5 [1,9] View
51 Trifluormethazolamide 3.9E-6 [1] View
52 Yohimbine 1.8E-5 [5] View
53 Cinoxacin 1.5E-6 [10] View
54 Nalidixic acid 1.7E-5 [10] View
55 Enoxacin 1.7E-6 [10] View
56 Norfloxacin 1.4E-6 [10] View
57 Ofloxacin 1.9E-6 [10] View
58 Ciprofloxacin 1.3E-6 [10] View
59 Moxifloxacin 9.1E-6 [11] View
60 Levofloxacin 2.9E-6 [11] View
61 Gatifloxacin 2.5E-6 [11] View
62 Lomefloxacin 3.5E-6 [11] View
63 Buspirone 6.65E-5 [11] View
64 Apraclonidine 3.8E-6 [11] View
65 Fluorescein 1.6E-5 [11] View
66 Pilocarpine 9.8E-6 [11] View
67 Nepafenac 7.4E-5 [11] View
68 Betaxolol 6.0E-5 [11] View
69 Dexamethasone 9.2E-6 [11] View

Bibliography

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  9. WU, N.-C.; CHIANG, C.-H.; LEE, A.-R. Studies of Carbonic Anhydrase Inhibitors: Physicochemical Properties and Bioactivities of New Thiadiazole Derivatives. Journal of Ocular Pharmacology and Therapeutics 1993, 9, 97–108. http://dx.doi.org/10.1089/jop.1993.9.97

  10. Jankowska, L. M.; Bar-Ilan, A.; Maren, T. The relations between ionic and non-ionic diffusion of sulfonamides across the rabbit cornea. Investigative ophthalmology & visual science 1986, 27, 29-37.

  11. Rusinko, A.; Hellberg, M. R.; May, J. A.; Owen, G. R. Use of mdck cell line to predict corneal penetration of drugs. 2008.