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10967/191 - QDB Compounds

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Kidron, H.; Vellonen, K.-S.; del Amo, E. M.; Tissari, A.; Urtti, A. Prediction of the Corneal Permeability of Drug-Like Compounds. Pharm. Res. 2010, 27, 1398–1407.

69 compounds | Property logPapp: The logarithm of the corneal permeability [log(cm/s)]

ID Name logPapp Ref Details
1 Acetazolamide -6.04 [1,2] View
2 Alprenolol -4.54 [3] View
3 Atenolol -6.17 [4] View
4 Benzolamide -6.85 [1] View
5 Bevantolol -4.27 [4] View
6 N-bromoacetazolamide -6.42 [1] View
7 Bufuralol -4.24 [4] View
8 Chlorzolamide -4.74 [1] View
9 Clonidine -4.51 [3,5] View
10 Corynanthine -4.96 [5] View
11 Cyclophosphamide -4.96 [6] View
12 Ethoxazolamide -4.25 [1] View
13 2-benzothiazolesulfonamide -4.44 [7] View
14 6-hydroxy-2-benzo-thiazolesulfonamide -5.25 [7] View
15 6-chloro-2-benzo-thiazolesulfonamide -4.37 [7] View
16 4,6-dichloro-2-benzo-thiazolesulfonamide -4.41 [7] View
17 6-amino-2-benzo-thiazolesulfonamide -5.17 [7] View
18 6-nitro-2-benzo-thiazolesulfonamide -5.18 [7] View
19 6-hydroxyethoxy-2-benzothiazolesulfonamide -5.82 [7] View
20 6-benzyloxy-2-benzo-thiazolesulfonamide -4.33 [7] View
21 6-acetamido-2-benzo-thiazolesulfonamide -5.33 [7] View
22 Levobunolol -4.7 [3,4] View
23 Labetalol -4.85 [3] View
24 Methazolamide -5.59 [1] View
25 5-imino-4-methyl-1,3,4-thiadiazoline-2-sulfonamide -6.11 [1] View
26 Metoprolol -4.6 [3,4] View
27 Nadolol -6 [4] View
28 Oxprenolol -4.54 [3,4] View
29 Penbutolol -4.35 [4] View
30 Phenylephrine -6.03 [5] View
31 Pindolol -5 [3] View
32 Propranolol -4.32 [4] View
33 Rauwolfine -5.04 [5] View
34 6H,7H,8H,9H-[1,2,3]thiadiazolo[5,4-h]isoquinoline i -4.1 [5] View
35 Benalfocin i -4.15 [5] View
36 5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline i -4.31 [5] View
37 Sotalol -5.8 [4] View
38 1[(N-methylamino) sulfonyl]-4-chloro-benzene -4.19 [2] View
39 4-chlorobenzene-1-sulfonamide -4.26 [2] View
40 (3Z)-3-(phenylimino)-[1,2,4]thiadiazolo[3,4-b][1,3,4]thiadiazole-6-sulfonamide i -5.1 [8] View
41 (3Z)-3-[(3-chlorophenyl)imino]-[1,2,4]thiadiazolo[3,4-b][1,3,4]thiadiazole-6-sulfonamide i -4.89 [8] View
42 (3Z)-3-[(4-chlorophenyl)imino]-[1,2,4]thiadiazolo[3,4-b][1,3,4]thiadiazole-6-sulfonamide i -5.08 [8] View
43 (3Z)-3-[(3-methoxyphenyl)imino]-[1,2,4]thiadiazolo[3,4-b][1,3,4]thiadiazole-6-sulfonamide i -5.35 [8] View
44 (3Z)-3-[(4-methoxyphenyl)imino]-[1,2,4]thiadiazolo[3,4-b][1,3,4]thiadiazole-6-sulfonamide i -5.28 [8] View
45 (3Z)-3-[(4-hydroxyphenyl)imino]-[1,2,4]thiadiazolo[3,4-b][1,3,4]thiadiazole-6-sulfonamide i -6.46 [8] View
46 (3Z)-3-[(3-fluorophenyl)imino]-[1,2,4]thiadiazolo[3,4-b][1,3,4]thiadiazole-6-sulfonamide i -5.19 [8] View
47 (3Z)-3-[(4-fluorophenyl)imino]-[1,2,4]thiadiazolo[3,4-b][1,3,4]thiadiazole-6-sulfonamide i -5.39 [8] View
48 (3Z)-3-{[4-(dimethylamino)phenyl]imino}-[1,2,4]thiadiazolo[3,4-b][1,3,4]thiadiazole-6-sulfonamide i -5.24 [8] View
49 Timolol -4.92 [3,4] View
50 Trichlormethazolamide -4.96 [1,9] View
51 Trifluormethazolamide -5.41 [1] View
52 Yohimbine -4.74 [5] View
53 Cinoxacin -5.82 [10] View
54 Nalidixic acid -4.77 [10] View
55 Enoxacin -5.77 [10] View
56 Norfloxacin -5.85 [10] View
57 Ofloxacin -5.72 [10] View
58 Ciprofloxacin -5.89 [10] View
59 Moxifloxacin -5.04 [11] View
60 Levofloxacin -5.54 [11] View
61 Gatifloxacin -5.6 [11] View
62 Lomefloxacin -5.46 [11] View
63 Buspirone -4.18 [11] View
64 Apraclonidine -5.42 [11] View
65 Fluorescein -4.8 [11] View
66 Pilocarpine -5.01 [11] View
67 Nepafenac -4.13 [11] View
68 Betaxolol -4.22 [11] View
69 Dexamethasone -5.04 [11] View

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  11. Rusinko, A.; Hellberg, M. R.; May, J. A.; Owen, G. R. Use of mdck cell line to predict corneal penetration of drugs. 2008.