Kidron, H.; Vellonen, K.-S.; del Amo, E. M.; Tissari, A.; Urtti, A. Prediction of the Corneal Permeability of Drug-Like Compounds. Pharm. Res. 2010, 27, 1398–1407.
Compound
| ID: | 33 | |
|---|---|---|
| Name: | Rauwolfine | |
| Description: | ||
| Labels: | ||
| CAS: | ||
| InChi Code: | InChI=1/C20H26N2O2/c1-3-10-11-8-14-17-20(12-6-4-5-7-13(12)21(17)2)9-15(16(11)18(20)23)22(14)19(10)24/h4-7,10-11,14-19,23-24H,3,8-9H2,1-2H3 |
Properties
perm: Corneal permeability [cm/s]
| Value | Source or prediction |
|---|---|
| 9.2E-6 |
Chiang, C.-H.; Schoenwald, R. D. Ocular pharmacokinetic models of clonidine-3H hydrochloride. Journal of Pharmacokinetics and Biopharmaceutics 1986, 14, 175–211. http://dx.doi.org/10.1007/bf01065260 |
logPapp: The logarithm of the corneal permeability [log(cm/s)]
| Value | Source or prediction |
|---|---|
| -5.04 |
Chiang, C.-H.; Schoenwald, R. D. Ocular pharmacokinetic models of clonidine-3H hydrochloride. Journal of Pharmacokinetics and Biopharmaceutics 1986, 14, 175–211. http://dx.doi.org/10.1007/bf01065260 |
| -4.64 |
Eq.3b: Model for drug-like compounds at pH 7.4 (Trainig set) |
| -4.65 |
Eq.4b: Model for drug-like compounds at pH 8.0 (Trainig set) |