Kidron, H.; Vellonen, K.-S.; del Amo, E. M.; Tissari, A.; Urtti, A. Prediction of the Corneal Permeability of Drug-Like Compounds. Pharm. Res. 2010, 27, 1398–1407.
Compound
| ID: | 2 | |
|---|---|---|
| Name: | Alprenolol | |
| Description: | ||
| Labels: | ||
| CAS: | ||
| InChi Code: | InChI=1S/C15H23NO2/c1-4-7-13-8-5-6-9-15(13)18-11-14(17)10-16-12(2)3/h4-6,8-9,12,14,16-17H,1,7,10-11H2,2-3H3 |
Properties
perm: Corneal permeability [cm/s]
| Value | Source or prediction |
|---|---|
| 2.9E-5 |
Wang, W.; Sasaki, H.; Chien, D.-S.; Lee, V. H. L. Lipophilicity influence on conjunctival drug penetration in the pigmented rabbit: A comparison with corneal penetration. Current Eye Research 1991, 10, 571–579. http://dx.doi.org/10.3109/02713689109001766 |
logPapp: The logarithm of the corneal permeability [log(cm/s)]
| Value | Source or prediction |
|---|---|
| -4.54 |
Wang, W.; Sasaki, H.; Chien, D.-S.; Lee, V. H. L. Lipophilicity influence on conjunctival drug penetration in the pigmented rabbit: A comparison with corneal penetration. Current Eye Research 1991, 10, 571–579. http://dx.doi.org/10.3109/02713689109001766 |
| -4.49 |
Eq.3b: Model for drug-like compounds at pH 7.4 (Trainig set) |
| -4.4 |
Eq.4b: Model for drug-like compounds at pH 8.0 (Trainig set) |
Links to External Resources
| Link | Resource description |
|---|---|
| DTXSID0045127 | US EPA CompTox Dashboard |