Kidron, H.; Vellonen, K.-S.; del Amo, E. M.; Tissari, A.; Urtti, A. Prediction of the Corneal Permeability of Drug-Like Compounds. Pharm. Res. 2010, 27, 1398–1407.
Compound
| ID: | 15 | |
|---|---|---|
| Name: | 6-chloro-2-benzo-thiazolesulfonamide | |
| Description: | ||
| Labels: | ||
| CAS: | ||
| InChi Code: | InChI=1S/C7H5ClN2O2S2/c8-4-1-2-5-6(3-4)13-7(10-5)14(9,11)12/h1-3H,(H2,9,11,12) |
Properties
perm: Corneal permeability [cm/s]
| Value | Source or prediction |
|---|---|
| 4.3E-5 |
Schoenwald, R. D.; Houseman, J. A. Disposition of cyclophosphamide in the rabbit and human cornea. Biopharmaceutics & Drug Disposition 1982, 3, 231–241. http://dx.doi.org/10.1002/bdd.2510030306 |
logPapp: The logarithm of the corneal permeability [log(cm/s)]
| Value | Source or prediction |
|---|---|
| -4.37 |
Schoenwald, R. D.; Houseman, J. A. Disposition of cyclophosphamide in the rabbit and human cornea. Biopharmaceutics & Drug Disposition 1982, 3, 231–241. http://dx.doi.org/10.1002/bdd.2510030306 |
| -4.42 |
Eq.3b: Model for drug-like compounds at pH 7.4 (Trainig set) |
| -4.52 |
Eq.4b: Model for drug-like compounds at pH 8.0 (Trainig set) |