10967/129 - QDB Compounds

QsarDB Repository

Veith, G.D.; Petkova, E.P.; Wallace, K.B. A baseline inhalation toxicity model for narcosis in mammals. SAR QSAR Environ. Res. 2009, 20, 5-6, 567–578.

41 compounds | Property logLC50exp: Acute inhalation toxicity in rats as log(LC50) [log(mmol/m3)]

IDNamelogLC50expRefDetails
11,1,1-Trichloroethane2.88[1]View
21,1,2-Trichloro-1,2,2-trifluoroethane3.44[1]View
31,1-Dichloro-1-fluoroethane i3.38[1]View
41,3-Dichloropropane2.50[2]View
51,3-Dichloro-1,1,2,2,3-pentafluoropropane i3.18[3]View
62-Butoxyethanol1.28[4]View
72-Propanol2.93[5]View
83,3-Dichloro-1,1,1,2,2-pentafluoropropane3.18[3]View
9Acetone3.04[6]View
10Acetonitrile2.77[7]View
11Butadiene3.72[8]View
12Butane4.05[8]View
13Butyl alcohol2.60[6]View
142-Ethoxylethanol1.91[6]View
152-Ethoxyethyl acetate1.96[6]View
16Cyclohexanone2.03[9]View
17Dioxane2.76[6]View
18Ethyl acetate2.66[10]View
19Ethylidene norbornene1.85[6]View
20Hexane3.24[11]View
211-Hexene i3.14[11]View
222-Hexene i3.13[6]View
23Isobutanol2.39[8]View
24Isobutylene4.04[8]View
25Isoprene3.42[6]View
26Isopropanol2.66[6]View
27Isopropyl acetate2.69[6]View
28Methanol3.27[6]View
29Methyl ethyl ketone2.51[6]View
30Methyl isobutyl ketone2.06[6]View
31n-Butyl acetate2.54[12]View
32n-Nonane2.12[6]View
33Perchlorethylene2.31[8]View
34Styrene2.05[8]View
35Toluene2.31[6]View
361,1,2-Trichloroethylene2.69[6]View
37Acrolein-0.52[13]View
38Acetaldehyde2.74[14]View
39Ethyl acrylate1.95[15]View
40Hydrogen sulfide1.26[16]View
41Methyl mercaptan1.45[17]View

Bibliography

  1. Company, D. C. An acute vapor inhalation study in Fischer 344 rats. 1988, OTS0509711-6.

  2. Tunstall, S. T. L.- The toxicology of fine chemicals. The acute 4-hour inhalation LC50 of 1,3-dichloropropane in rats. 1982, OTS0510356.

  3. Brock, W. J.; Shin-Ya, S.; Rusch, G. M.; Hardy, C. J.; Trochimowicz, H. J. Inhalation toxicity and genotoxicity of hydrochlorofluorocarbon HCFC-225ca and HCFC-225cb. Journal of Applied Toxicology 1999, 19, 101-112. http://dx.doi.org/10.1002/(SICI)1099-1263(199903/04)19:2<101::AID-JAT546>3.0.CO;2-R

  4. Dodd, D. E.; Snellings, W. M.; Maronpot, R. R.; Ballantyne, B. Ethylene glycol monobutyl ether: Acute, 9-day, and 90-day vapor inhalation studies in Fischer 344 rats. Toxicology and Applied Pharmacology 1983, 68, 405-414. http://dx.doi.org/10.1016/0041-008X(83)90285-5

  5. Laham, S.; Potvin, M.; Schrader, K.; Marino, I. Studies on inhalation toxicology of 2-propanol. Drug and Chemical Toxicology 1980, 3, 343-360.

  6. Pozzani, U. C.; Weil, C. S.; Carpenter, C. P. The toxicological basis of threshold limit values: 5. The experimental inhalation of vapor mixtures by rats, with notes upon the relationship between single dose inhalation and single dose oral data. American Industrial Hygiene Association Journal 1959, 20, 364-369. http://dx.doi.org/10.1080/00028895909343733

  7. Pozzani, U. C.; Carpenter, C. P.; Palm, P. E.; Weil, C. S.; Nair, J. H. Mammalian toxicity of acetonitrile. Journal of Occupational Medicine 1959, 1, 634-642.

  8. Shugaev, B. Concentrations of hydrocarbons in tissues as a measure of toxicity. Archives of Environmental Health 1969, 18, 878-882. http://dx.doi.org/10.1080/00039896.1969.10665509

  9. Gupta, P. K.; Lawrence, W. H.; Turner, J. E.; J, A. Toxicological aspects of cyclohexanone. Toxicology and Applied Pharmacology 1979, 49, 525-533. http://dx.doi.org/10.1016/0041-008X(79)90454-X

  10. Kinkead, E. R.; Pozzani, U. C.; Geary, D. L.; Carpenter, C. R. The mammalian toxicity of ethylidenenorbornene (5-ethylidenebicyclo (2,1,1) hept-2-ene). Toxicology and Applied Pharmacology 1971, 20, 250-259. http://dx.doi.org/10.1016/0041-008X(71)90051-2

  11. Kennedy, J. L.; Graepel, G. J. Acute toxicity in the rat following either oral or inhalation exposure. Toxicology Letters 1991, 56, 317-326. http://dx.doi.org/10.1016/0378-4274(91)90160-8

  12. Carpenter, C. P.; Geary Jr., D. L.; Myers, R. C.; Nachreiner, D. J.; J, S. L.; King, J. M. Petroleum hydrocarbon toxicity studies XVII. Animal response to n-nonane vapour. Toxicology and Applied Pharmacology 1978, 44, 53-61. http://dx.doi.org/10.1016/0041-008X(78)90283-1

  13. Ballantyne, B.; Dodd, D. E.; Pritts, I. M.; Nachreiner, D. J.; Fowler, E. H. Acute vapour inhalation toxicity of acrolein and its influence as a trace contaminant in 2-methoxy-3,4-dihydro-2H-pyran. Human & Experimental Toxicology 1989, 8, 229-235. http://dx.doi.org/10.1177/096032718900800305

  14. Appelman, L. M.; Woutersen, R. A.; Feron, V. J. Inhalation toxicity of acetaldehyde in rats. I, acute and subacute studies. Toxicology 1982, 23, 293-307. http://dx.doi.org/10.1016/0300-483X(82)90068-3

  15. Oberly, R.; Tansy, M. F. LC50 values for rats acutely exposed to vapors of acrylic and methacrylic acid esters. Journal of Toxicology and Environmental Health 1985, 16, 811-822. http://dx.doi.org/10.1016/0300-483X(82)90068-3

  16. Tansy, M. F.; Kendall, F. M.; Fantasia, J.; Landin, W. E.; Oberly, R.; Sherman, W. Acute and subchronic toxicity sudies of rats exposed to vapors of methyl mercaptan and other reduced-sulfur compounds. Journal of Toxicology and Environmental Health 1981, 8, 71-88. http://dx.doi.org/10.1080/15287398109530051

  17. Marsh, D. F.; D, L. C. The comparative anesthetic activity of the aliphatic ethers. Anesthesiology 1950, 11, 455-463.